Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment

S Qi, N Duan, IM Khan, X Dong, Y Zhang, S Wu… - Biotechnology …, 2022 - Elsevier
Aptamers are short single-stranded DNA or RNA oligonucleotides isolated from randomized
libraries, presenting high affinity and specificity toward targets with similar to antibodies …

A comprehensive review of oyster peptides: Preparation, characterisation and bioactivities

L Hao, X Wang, Y Cao, J Xu, C Xue - Reviews in Aquaculture, 2022 - Wiley Online Library
Oysters are a healthy and excellent source of lean protein (content up to 45%–57%). In
addition, polypeptides extracted from hydrolysis of oyster protein by enzymatic hydrolysis or …

[HTML][HTML] Technological interventions in improving the functionality of proteins during processing of meat analogs

P Kumar, N Sharma, MA Ahmed, AK Verma… - Frontiers in …, 2022 - frontiersin.org
Meat analogs have opened a new horizon of opportunities for developing a sustainable
alternative for meat and meat products. Proteins are an integral part of meat analogs and …

Peptidomimetics in cancer targeting

MM Gomari, S Abkhiz, TG Pour, E Lotfi, N Rostami… - Molecular …, 2022 - Springer
The low efficiency of treatment strategies is one of the main obstacles to developing cancer
inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer …

Toxicity of trastuzumab for breast cancer spheroids: application of a novel on-a-chip concentration gradient generator

S Shahrivari, N Aminoroaya, R Ghods, H Latifi… - Biochemical …, 2022 - Elsevier
Evaluating the effectiveness of drugs on an individual basis before prescribing them has an
influential role in choosing a successful treatment plan. The advent of microfluidic devices …

Evaluation of pH change effects on the HSA folding and its drug binding characteristics, a computational biology investigation

MM Gomari, N Rostami, DR Faradonbeh… - Proteins: Structure …, 2022 - Wiley Online Library
The binding of therapeutics to human serum albumin (HSA), which is an abundant protein in
plasma poses a major challenge in drug discovery. Although HSA has several binding …

Engineering his-tagged senecavirus a for one-step purification of viral antigens

J Fan, P Xiao, D Kong, X Liu, L Meng, T An, X Cai… - Vaccines, 2022 - mdpi.com
Senecavirus A (SVA) is a picornavirus that causes vesicular disease in swine, and the
inactivated vaccine is used to prevent and control SVA infection. To develop a new …

A cleavable self-aggregating tag scheme for the expression and purification of disulfide bonded proteins and peptides

Z Lin, Y Jing, Y Huang, S Yang, S Chen, Y Ou… - Chemical Engineering …, 2022 - Elsevier
The production of correctly folded, disulfide bonded proteins in high yields remains a
technological challenge, especially for the commonly used expression system Escherichia …

Recent advances in siRNA delivery systems for prostate cancer therapy

S Aghamiri, P Raee… - Current …, 2022 - ingentaconnect.com
The critical problems of conventional prostate cancer therapeutic strategies like nonspecific
toxicity and multi-drug resistance prompted the development and application of countless …

[HTML][HTML] Expression, purification, and kinetic characterization of the human strep-IDO1

D Saimi, Z Wang, Q Zhu, J Lv - Translational Cancer Research, 2022 - ncbi.nlm.nih.gov
Background Tryptophan catabolism leading to T cell suppression mediated by indoleamine
2, 3-dioxygenase (IDO1) is an important mechanism of tumor immune escape, and IDO1 …