The signaling pathways of traditional Chinese medicine in promoting diabetic wound healing

X Zhou, Y Guo, K Yang, P Liu, J Wang - Journal of Ethnopharmacology, 2022 - Elsevier
Ethnopharmacological relevance The diabetic wound is one of the common chronic
complications of diabetes, which seriously affects patients' quality of life and even causes …

The role of the human microbiome in the pathogenesis of pain

K Ustianowska, Ł Ustianowski, F Machaj… - International Journal of …, 2022 - mdpi.com
Understanding of the gut microbiome's role in human physiology developed rapidly in recent
years. Moreover, any alteration of this microenvironment could lead to a pathophysiological …

Neuroimmune cardiovascular interfaces control atherosclerosis

SK Mohanta, L Peng, Y Li, S Lu, T Sun, L Carnevale… - Nature, 2022 - nature.com
Atherosclerotic plaques develop in the inner intimal layer of arteries and can cause heart
attacks and strokes. As plaques lack innervation, the effects of neuronal control on …

Skin‐inspired thermoreceptors‐based electronic skin for biomimicking thermal pain reflexes

J Neto, R Chirila, AS Dahiya, A Christou… - Advanced …, 2022 - Wiley Online Library
Electronic systems possessing skin‐like morphology and functionalities (electronic skins [e‐
skins]) have attracted considerable attention in recent years to provide sensory or haptic …

Corneal nerves and their role in dry eye pathophysiology

A Vereertbrugghen, JG Galletti - Experimental Eye Research, 2022 - Elsevier
As the cornea is densely innervated, its nerves are integral not only to its structure but also to
its pathophysiology. Corneal integrity depends on a protective tear film that is maintained by …

The role of TRP ion channels in migraine and headache

LF Iannone, F De Logu, P Geppetti, F De Cesaris - Neuroscience letters, 2022 - Elsevier
Migraine afflicts more than 10% of the general population. Although its mechanism is poorly
understood, recent preclinical and clinical evidence has identified calcitonin gene related …

The interplay between chronic pain, opioids, and the immune system

V Malafoglia, S Ilari, L Vitiello, M Tenti… - The …, 2022 - journals.sagepub.com
Chronic pain represents one of the most serious worldwide medical problems, in terms of
both social and economic costs, often causing severe and intractable physical and …

[HTML][HTML] Review of techniques useful for the assessment of sensory small fiber neuropathies: report from an IFCN expert group

RJ Verdugo, JM Matamala, K Inui, R Kakigi… - Clinical …, 2022 - Elsevier
Nerve conduction studies (NCS) are an essential aspect of the assessment of patients with
peripheral neuropathies. However, conventional NCS do not reflect activation of small …

A novel spinal neuron connection for heat sensation

H Wang, W Chen, Z Dong, G Xing, W Cui, L Yao… - Neuron, 2022 - cell.com
Heat perception enables acute avoidance responses to prevent tissue damage and
maintain body thermal homeostasis. Unlike other modalities, how heat signals are …

[HTML][HTML] Molecular mechanisms linking stress and insulin resistance

H Yaribeygi, M Maleki, AE Butler, T Jamialahmadi… - EXCLI …, 2022 - ncbi.nlm.nih.gov
To date, there is ample evidence to support the strong relationship between stress and
insulin resistance. While diabetes mellitus acts as a potent stress inducer, stress may be an …