Gut microbiota: A promising milestone in enhancing the efficacy of PD1/PD-L1 blockade therapy

Y Zhou, Z Liu, T Chen - Frontiers in Oncology, 2022 - frontiersin.org
In the past few decades, immunotherapy has emerged as one of the most promising
strategies among current treatments of cancer. In particular, the field of PD1/PD-L1 inhibitors …

Dietary influences on symptomatic and non-symptomatic toxicities during cancer treatment: A narrative review

AJ Kim, DS Hong, GC George - Cancer treatment reviews, 2022 - Elsevier
The general nutritional status of cancer patients could be a central determinant of cancer
treatment-related toxicity and an indicator of cancer symptoms such as cancer-related …

Lacticaseibacillus paracasei sh2020 induced antitumor immunity and synergized with anti-programmed cell death 1 to reduce tumor burden in mice

SL Zhang, B Han, YQ Mao, ZY Zhang, ZM Li… - Gut …, 2022 - Taylor & Francis
The gut microbiota was emerging as critical regulatory elements in shaping the outcome of
cancer immunotherapy. However, the underlying mechanisms by which the gut commensal …

Bifidobacterium longum subsp. longum 51A attenuates intestinal injury against irinotecan-induced mucositis in mice

MF Quintanilha, VC Miranda, RO Souza, B Gallotti… - Life Sciences, 2022 - Elsevier
Intestinal mucositis (IM) is a critical side-effect associated with antineoplastic therapy.
Treatment available is only palliative and often not effective. However, alternative …

[HTML][HTML] Wumei pills attenuates 5-fluorouracil-induced intestinal mucositis through Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB pathway and …

DX Lu, F Liu, H Wu, HX Liu, BY Chen… - World Journal of …, 2022 - ncbi.nlm.nih.gov
BACKGROUND Radiotherapy and chemotherapy can kill tumor cells and improve the
survival rate of cancer patients. However, they can also damage normal cells and cause …

Akkermansia muciniphila and its outer membrane protein Amuc_1100 prophylactically attenuate 5-fluorouracil-induced intestinal mucositis

S Chen, K Qian, G Zhang, M Zhang - Biochemical and biophysical research …, 2022 - Elsevier
Fluorouracil (5-FU) is a chemotherapy drug used to treat tumors. Previous studies have
shown that Akkermansia muciniphila (A. muciniphila) and its outer membrane protein …

[HTML][HTML] Paraprobiotic Enterococcus faecalis EC-12 prevents the development of irinotecan-induced intestinal mucositis in mice

LMS Nobre, MH da Silva Lopes, J Geraix, AG Cajado… - Life Sciences, 2022 - Elsevier
Aims This study tested the protective effect of purified paraprobiotic Enterococcus faecalis
(EC-12) and an E. faecalis-based formulation (Med Lansingle bondS) on irinotecan-induced …

[HTML][HTML] Non-pharmacologic strategies for the management of intestinal inflammation

TU Maioli, LM Trindade, A Souza, L Torres… - Biomedicine & …, 2022 - Elsevier
Inflammatory bowel diseases, irritable bowel syndrome, and mucositis are characterized by
intestinal inflammation, but vary according to their pathological mechanisms, severity …

Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats

D Dahlgren, E Rosenqvist, PM Hellström… - Basic & Clinical …, 2022 - Wiley Online Library
Chemotherapy‐induced mucositis is characterized by diarrhoea and villous atrophy.
However, it is not well‐understood why diarrhoea arises, why it only occurs with some …

Bugs as drugs: neglected but a promising future therapeutic strategy in cancer

M Divyashree, SK Prakash, V Aditya, AAA Aljabali… - Future …, 2022 - Taylor & Francis
Effective cancer treatment is an urgent need due to the rising incidence of cancer. One of the
most promising future strategies in cancer treatment is using microorganisms as cancer …