[HTML][HTML] Leptin signaling in obesity and colorectal cancer
CT Socol, A Chira, MA Martinez-Sanchez… - International journal of …, 2022 - mdpi.com
Obesity and colorectal cancer (CRC) are among the leading diseases causing deaths in the
world, showing a complex multifactorial pathology. Obesity is considered a risk factor in …
world, showing a complex multifactorial pathology. Obesity is considered a risk factor in …
[HTML][HTML] A saturated map of common genetic variants associated with human height
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–
50% of phenotypic variation in human height, but identifying the specific variants and …
50% of phenotypic variation in human height, but identifying the specific variants and …
[HTML][HTML] Genetic control of RNA splicing and its distinct role in complex trait variation
Most genetic variants identified from genome-wide association studies (GWAS) in humans
are noncoding, indicating their role in gene regulation. Previous studies have shown …
are noncoding, indicating their role in gene regulation. Previous studies have shown …
A review of SNP heritability estimation methods
M Tang, T Wang, X Zhang - Briefings in bioinformatics, 2022 - academic.oup.com
Over the past decade, statistical methods have been developed to estimate single
nucleotide polymorphism (SNP) heritability, which measures the proportion of phenotypic …
nucleotide polymorphism (SNP) heritability, which measures the proportion of phenotypic …
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data
Analyses of data from genome-wide association studies on unrelated individuals have
shown that, for human traits and diseases, approximately one-third to two-thirds of …
shown that, for human traits and diseases, approximately one-third to two-thirds of …
Plant genetic effects on microbial hubs impact host fitness in repeated field trials
B Brachi, D Filiault, H Whitehurst… - Proceedings of the …, 2022 - National Acad Sciences
Although complex interactions between hosts and microbial associates are increasingly well
documented, we still know little about how and why hosts shape microbial communities in …
documented, we still know little about how and why hosts shape microbial communities in …
[HTML][HTML] Meta-analysis fine-mapping is often miscalibrated at single-variant resolution
Meta-analysis is pervasively used to combine multiple genome-wide association studies
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …
[HTML][HTML] Genomic variants affecting homoeologous gene expression dosage contribute to agronomic trait variation in allopolyploid wheat
Allopolyploidy greatly expands the range of possible regulatory interactions among
functionally redundant homoeologous genes. However, connection between the emerging …
functionally redundant homoeologous genes. However, connection between the emerging …
[HTML][HTML] A cognitive neurogenetic approach to uncovering the structure of executive functions
One central mission of cognitive neuroscience is to understand the ontology of complex
cognitive functions. We addressed this question with a cognitive neurogenetic approach …
cognitive functions. We addressed this question with a cognitive neurogenetic approach …
Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation
Many genetic variants affect disease risk by altering context-dependent gene regulation.
Such variants are difficult to study mechanistically using current methods that link genetic …
Such variants are difficult to study mechanistically using current methods that link genetic …