Long-acting antiretrovirals: a new era for the management and prevention of HIV infection
P Thoueille, E Choong, M Cavassini… - Journal of …, 2022 - academic.oup.com
The long-acting antiretroviral cabotegravir and rilpivirine combination has just received FDA,
EMA and Health Canada approval. This novel drug delivery approach is about to …
EMA and Health Canada approval. This novel drug delivery approach is about to …
Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges
V Agrahari, SM Anderson, MM Peet… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Poor or inconsistent adherence to daily oral pre-exposure prophylaxis (PrEP)
has emerged as a key barrier to effective HIV prevention. The advent of potent long-acting …
has emerged as a key barrier to effective HIV prevention. The advent of potent long-acting …
Indocyanine green potentiated paclitaxel nanoprodrugs for imaging and chemotherapy
X Xiang, X Feng, S Lu, B Jiang, D Hao, Q Pei… - …, 2022 - Wiley Online Library
Self‐assembled prodrug nanoparticles with tumor‐responsive capacity have great potential
in tumor visualization and treatment. However, the nanoparticle formulas usually contain …
in tumor visualization and treatment. However, the nanoparticle formulas usually contain …
Transformation of dolutegravir into an ultra-long-acting parenteral prodrug formulation
Ultra-long-acting integrase strand transfer inhibitors were created by screening a library of
monomeric and dimeric dolutegravir (DTG) prodrug nanoformulations. This led to an 18 …
monomeric and dimeric dolutegravir (DTG) prodrug nanoformulations. This led to an 18 …
[HTML][HTML] Oral antivirals for the prevention and treatment of SARS-CoV-2 infection
Vaccines and antivirals are the classical weapons deployed to contain, prevent, and treat life-
threatening viral illnesses. Specifically, for SARS-CoV-2 infection, vaccines protect against …
threatening viral illnesses. Specifically, for SARS-CoV-2 infection, vaccines protect against …
Non-viral vectors for delivery of nucleic acid therapies for cancer
The research and development of non-viral gene therapy has been extensive over the past
decade and has received a big push thanks to the recent successful approval of non-viral …
decade and has received a big push thanks to the recent successful approval of non-viral …
Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities
C Bassand, A Villois, L Gianola, G Laue… - Expert opinion on …, 2022 - Taylor & Francis
Introduction We see a development in the field of long-acting products to serve patients with
chronic diseases by providing benefits in adherence, efficacy, and safety of the treatment …
chronic diseases by providing benefits in adherence, efficacy, and safety of the treatment …
Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections
Peptides and peptide-based materials have an increasing role in the treatment of viral
infections through their use as active pharmaceutical ingredients, targeting moieties …
infections through their use as active pharmaceutical ingredients, targeting moieties …
[HTML][HTML] Ultra-long-acting (XLA) antivirals for chronic viral hepatitis
Viral hepatitis is among the top four causes of mortality globally, causing 1.4 million deaths
each year, exceeding tuberculosis, malaria and human immunodeficiency virus. Hepatitis B …
each year, exceeding tuberculosis, malaria and human immunodeficiency virus. Hepatitis B …
Pharmacokinetics of long-acting aqueous nano-/microsuspensions after intramuscular administration in different animal species and humans—a review
VTT Nguyen, N Darville, A Vermeulen - The AAPS Journal, 2022 - Springer
Formulating aqueous suspensions is an attractive strategy to incorporate poorly water-
soluble drugs, where the drug release can be tailored to maintain desired release profiles of …
soluble drugs, where the drug release can be tailored to maintain desired release profiles of …