Long-acting antiretrovirals: a new era for the management and prevention of HIV infection

P Thoueille, E Choong, M Cavassini… - Journal of …, 2022 - academic.oup.com
The long-acting antiretroviral cabotegravir and rilpivirine combination has just received FDA,
EMA and Health Canada approval. This novel drug delivery approach is about to …

Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges

V Agrahari, SM Anderson, MM Peet… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Poor or inconsistent adherence to daily oral pre-exposure prophylaxis (PrEP)
has emerged as a key barrier to effective HIV prevention. The advent of potent long-acting …

Indocyanine green potentiated paclitaxel nanoprodrugs for imaging and chemotherapy

X Xiang, X Feng, S Lu, B Jiang, D Hao, Q Pei… - …, 2022 - Wiley Online Library
Self‐assembled prodrug nanoparticles with tumor‐responsive capacity have great potential
in tumor visualization and treatment. However, the nanoparticle formulas usually contain …

Transformation of dolutegravir into an ultra-long-acting parenteral prodrug formulation

S Deodhar, B Sillman, AN Bade, SN Avedissian… - Nature …, 2022 - nature.com
Ultra-long-acting integrase strand transfer inhibitors were created by screening a library of
monomeric and dimeric dolutegravir (DTG) prodrug nanoformulations. This led to an 18 …

[HTML][HTML] Oral antivirals for the prevention and treatment of SARS-CoV-2 infection

V Soriano, C De-Mendoza, B Edagwa, A Treviño… - AIDS …, 2022 - ncbi.nlm.nih.gov
Vaccines and antivirals are the classical weapons deployed to contain, prevent, and treat life-
threatening viral illnesses. Specifically, for SARS-CoV-2 infection, vaccines protect against …

Non-viral vectors for delivery of nucleic acid therapies for cancer

S Kanvinde, T Kulkarni, S Deodhar, D Bhattacharya… - BioTech, 2022 - mdpi.com
The research and development of non-viral gene therapy has been extensive over the past
decade and has received a big push thanks to the recent successful approval of non-viral …

Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities

C Bassand, A Villois, L Gianola, G Laue… - Expert opinion on …, 2022 - Taylor & Francis
Introduction We see a development in the field of long-acting products to serve patients with
chronic diseases by providing benefits in adherence, efficacy, and safety of the treatment …

Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections

MK Monroe, H Wang, CF Anderson, H Jia… - Journal of Controlled …, 2022 - Elsevier
Peptides and peptide-based materials have an increasing role in the treatment of viral
infections through their use as active pharmaceutical ingredients, targeting moieties …

[HTML][HTML] Ultra-long-acting (XLA) antivirals for chronic viral hepatitis

V Soriano, C Alvarez, B Edagwa, C de Mendoza… - International Journal of …, 2022 - Elsevier
Viral hepatitis is among the top four causes of mortality globally, causing 1.4 million deaths
each year, exceeding tuberculosis, malaria and human immunodeficiency virus. Hepatitis B …

Pharmacokinetics of long-acting aqueous nano-/microsuspensions after intramuscular administration in different animal species and humans—a review

VTT Nguyen, N Darville, A Vermeulen - The AAPS Journal, 2022 - Springer
Formulating aqueous suspensions is an attractive strategy to incorporate poorly water-
soluble drugs, where the drug release can be tailored to maintain desired release profiles of …