Acute and chronic cutaneous wounds pose a significant health and economic burden.
Cutaneous wound healing is a complex process that occurs in four distinct, yet overlapping …

Besides their primary role in hemostasis, platelets contain a plethora of immunomodulatory
molecules that profoundly affect the entire process of wound repair. Therefore, platelet …

Macrophages regulate cutaneous wound healing by immune surveillance, tissue repair and
remodelling. The depletion of dermal macrophages during the early and middle stages of …

Bacterial toxins are thought to play a role in delayed wound healing in critically colonised
and infected wounds. Endotoxins are released from Gram-negative bacteria when they are …

Background NETosis is a neutrophil-mediated defense mechanism during which DNA and
enzymes are extruded forming a network (NETs) trapping and killing different pathogens …

We tried to unveil the clinical significance of miR-146a as a biomarker in M2 macrophage
polarization in diabetic wound healing. Initially, we found reduced miR-146a in …

The wound healing response is one of most primitive and conserved physiological
responses in the animal kingdom, as restoring tissue integrity/homeostasis can be the …

TLR4 plays a pivotal role in orchestrating inflammation and tissue repair. Its expression has
finally been balanced to initiate the early, robust immune response necessary for efficient …

Abstract Purpose In the skin, Lucilia sericata maggot excretions/secretions (ES) accelerate
wound healing and limit inflammation. This study aimed to determine whether ES have …

As a part of innate immunity, toll-like receptor 2 (TLR2) plays an important function in most
defensive responses of the organism, including but not limited to infections. Cutaneous …