Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Estimating the effects of variants found in disease driver genes opens the door to
personalized therapeutic opportunities. Clinical associations and laboratory experiments …

From 1994 through 2021, The International Agency for Research on Cancer (IARC) and the
World Health Organization maintained a comprehensive database on variations in the tumor …

Missense driver mutations in cancer are concentrated in a few hotspots. Various
mechanisms have been proposed to explain this skew, including biased mutational …

The tumor suppressor protein p53 is inactivated in the majority of human cancers and
remains a prime target for developing new drugs to reactivate its tumor suppressing activity …

Purpose: Head and neck squamous cell carcinoma (HNSCC) is a frequently devastating
cancer that affects more than a half million people annually worldwide. Although some …

Similar to neurodegenerative diseases, the concept that tumors are prion like diseases has
been proposed in recent years. p53, the most well-known tumor suppressor, has been …

Dysfunction of p53 is observed in many malignant tumors, which is related to cancer
susceptibility. In cervical cancer, p53 is primarily degradated through the complex of high …

The p53 tumor suppressor is a transcription factor with roles in cell development, apoptosis,
oncogenesis, aging, and homeostasis in response to stresses and infections. p53 is tightly …

The p53 protein has appropriately been named the “guardian of the genome”. In almost all
human cancers, the powerful tumor suppressor function of p53 is compromised by a variety …