Pathophysiology of primary cilia: signaling and proteostasis regulation
E Senatore, R Iannucci, F Chiuso… - Frontiers in Cell and …, 2022 - frontiersin.org
Primary cilia are microtubule-based, non-motile sensory organelles present in most types of
growth-arrested eukaryotic cells. They are transduction hubs that receive and transmit …
growth-arrested eukaryotic cells. They are transduction hubs that receive and transmit …
Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling
X Zhou, VE Torres - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Autosomal dominant polycystic kidney disease (ADPKD), with an estimated genetic
prevalence between 1: 400 and 1: 1,000 individuals, is the third most common cause of end …
prevalence between 1: 400 and 1: 1,000 individuals, is the third most common cause of end …
Interactome analysis of human phospholipase D and phosphatidic acid-associated protein network
Mammalian phospholipase D (PLD) enzyme family consists of six members. Among them,
PLD1/2/6 catalyzes phosphatidic acid (PA) production, while PLD3/4/5 has no catalytic …
PLD1/2/6 catalyzes phosphatidic acid (PA) production, while PLD3/4/5 has no catalytic …
Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth
R Delle Donne, R Iannucci, L Rinaldi… - Communications …, 2022 - nature.com
Glioblastoma multiforme (GBM) is the most frequent and aggressive form of primary brain
tumor in the adult population; its high recurrence rate and resistance to current therapeutics …
tumor in the adult population; its high recurrence rate and resistance to current therapeutics …
Identification of hub genes in bladder cancer based on weighted gene co‐expression network analysis from TCGA database
Background Muscular invasive bladder cancer (MIBC) is a common malignant tumor in the
world. Because of their heterogeneity in prognosis and response to treatment, biomarkers …
world. Because of their heterogeneity in prognosis and response to treatment, biomarkers …
Protein kinase A downregulation delays the development and progression of polycystic kidney disease
X Wang, L Jiang, K Thao, CR Sussman… - Journal of the …, 2022 - journals.lww.com
Background Upregulation of cAMP-dependent and cAMP-independent PKA signaling is
thought to promote cystogenesis in polycystic kidney disease (PKD). PKA-I regulatory …
thought to promote cystogenesis in polycystic kidney disease (PKD). PKA-I regulatory …
[HTML][HTML] Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth (587 visite)
L Lignitto, A Arcella, M Sepe, L Rinaldi… - Int J Mol Sc (ISSN: 1422 …, 2022 - ibb.cnr.it
Human glioblastoma is the most frequent and aggressive form of brain tumour in the adult
population. Proteolytic turnover of tumour suppressors by the ubiquitin-proteasome system …
population. Proteolytic turnover of tumour suppressors by the ubiquitin-proteasome system …