Gut-liver axis: Pathophysiological concepts and clinical implications

H Tilg, TE Adolph, M Trauner - Cell metabolism, 2022 - cell.com
Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …

Novel therapeutic targets for cholestatic and fatty liver disease

M Trauner, CD Fuchs - Gut, 2022 - gut.bmj.com
Cholestatic and non-alcoholic fatty liver disease (NAFLD) share several key
pathophysiological mechanisms which can be targeted by novel therapeutic concepts that …

EASL Clinical Practice Guidelines on sclerosing cholangitis

O Chazouilleres, U Beuers, A Bergquist, TH Karlsen… - Journal of …, 2022 - Elsevier
Management of primary or secondary sclerosing cholangitis is challenging. These Clinical
Practice Guidelines have been developed to provide practical guidance on debated topics …

Fecal microbiota transplantation as new therapeutic avenue for human diseases

M Biazzo, G Deidda - Journal of Clinical Medicine, 2022 - mdpi.com
The human body is home to a variety of micro-organisms. Most of these microbial
communities reside in the gut and are referred to as gut microbiota. Over the last decades …

Promises of microbiome-based therapies

JS Bajaj, SC Ng, B Schnabl - Journal of hepatology, 2022 - Elsevier
Humans harbour large quantities of microbes, including bacteria, fungi, viruses and
archaea, in the gut. Patients with liver disease exhibit changes in the intestinal microbiota …

The role of gut microbiota in some liver diseases: from an immunological perspective

L Wang, ZM Cao, LL Zhang, J Li, W Lv - Frontiers in immunology, 2022 - frontiersin.org
Gut microbiota is a microecosystem composed of various microorganisms. It plays an
important role in human metabolism, and its metabolites affect different tissues and organs …

Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases

Y Wang, S Zhang, TJ Borody, F Zhang - Chinese Medical Journal, 2022 - journals.lww.com
Fecal microbiota transplantation (FMT) has been used as a core therapy for treating
dysbiosis-related diseases by remodeling gut microbiota. The methodology and technology …

Gardenia jasminoides Ellis polysaccharide ameliorates cholestatic liver injury by alleviating gut microbiota dysbiosis and inhibiting the TLR4/NF-κB signaling pathway

S Fang, T Wang, Y Li, H Xue, J Zou, J Cai, R Shi… - International Journal of …, 2022 - Elsevier
Gardenia jasminoides Ellis is a well-known herbal medicine. In this study, the effect of G.
jasminoides Ellis polysaccharide (GPS) on liver injury in an alpha-naphthylisothiocyanate …

The gut microbiota: a novel player in autoimmune hepatitis

Z Cheng, L Yang, H Chu - Frontiers in cellular and infection …, 2022 - frontiersin.org
Autoimmune hepatitis (AIH) is a chronic immune-mediated liver disease distributed globally
in all ethnicities with increasing prevalence. If left untreated, the disease will lead to …

The intestinal and biliary microbiome in autoimmune liver disease—current evidence and concepts

T Liwinski, M Heinemann, C Schramm - Seminars in Immunopathology, 2022 - Springer
Autoimmune liver diseases are a group of immune-mediated liver diseases with three
distinct entities, including autoimmune hepatitis, primary biliary cholangitis, and primary …