The dopamine D1 receptor (D1R) is a Gαs/olf-coupled GPCR that is expressed in the
midbrain and forebrain, regulating motor behavior, reward, motivational states, and cognitive …

This review provides an overview of the synaptic dysfunctions of neuronal circuits and
underlying neurochemical alterations observed in the hyperkinetic movement disorders …

Dystonia is often associated with functional alterations in the cerebello-thalamic pathways,
which have been proposed to contribute to the disorder by propagating pathological firing …

Dopamine and other neurotransmitters have the potential to induce neuroplasticity in the
striatum via gene regulation. Dopamine receptor-mediated gene regulation relies on second …

Animals respond to changes in the environment and internal states to modify their behavior.
The basal ganglia, including the striatum contribute to action selection by integrating …