LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond

W Huang, H Li, Q Yu, W Xiao, DO Wang - Journal of Experimental & …, 2022 - Springer
DNA methylation is one of the most important epigenetic mechanisms to regulate gene
expression, which is highly dynamic during development and specifically maintained in …

Functional roles of lncRNA-TUG1 in hepatocellular carcinoma

M Farzaneh, M Ghasemian, F Ghaedrahmati… - Life Sciences, 2022 - Elsevier
Hepatocellular carcinoma (HCC) or hepatoma is malignant cancer that starts from the main
liver cells. Although various classical methods have been used for patients with HCC …

M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5 …

H Jiang, L Zhou, N Shen, X Ning, D Wu, K Jiang… - Cell death & …, 2022 - nature.com
Exosomes serve as a crucial mode of communication between tumor-associated
macrophages (TAMs) and cancer cells. This study attempted to explore the function of M1 …

Exosomal lncRNA TUG1 from cancer-associated fibroblasts promotes liver cancer cell migration, invasion, and glycolysis by regulating the miR-524-5p/SIX1 axis

L Lu, J Huang, J Mo, X Da, Q Li, M Fan, H Lu - Cellular & Molecular Biology …, 2022 - Springer
Background Increasing evidence suggests that taurine upregulated gene 1 (TUG1) is crucial
for tumor progression; however, its role in hepatocellular carcinoma (HCC) and the …

M2-like tumor-associated macrophage-related biomarkers to construct a novel prognostic signature, reveal the immune landscape, and screen drugs in hepatocellular …

X Qu, X Zhao, K Lin, N Wang, X Li, S Li… - Frontiers in …, 2022 - frontiersin.org
Background M2-like tumor-associated macrophages (M2-like TAMs) have important roles in
the progression and therapeutics of cancers. We aimed to detect novel M2-like TAM-related …

Heterogeneous graph attention network based on meta-paths for lncrna–disease association prediction

X Zhao, X Zhao, M Yin - Briefings in bioinformatics, 2022 - academic.oup.com
Motivation: Discovering long noncoding RNA (lncRNA)–disease associations is a
fundamental and critical part in understanding disease etiology and pathogenesis. However …

LncRNA Tug1 maintains blood–testis barrier integrity by modulating Ccl2 expression in high-fat diet mice

S Wang, Z Qian, X Ge, C Li, M Xue, K Liang… - Cellular and Molecular …, 2022 - Springer
Sertoli cells are essential for spermatogenesis in the testicular seminiferous tubules by
forming blood–testis barrier (BTB) and creating a unique microenvironment for …

Function of the long noncoding RNAs in hepatocellular carcinoma: classification, molecular mechanisms, and significant therapeutic potentials

A Khan, X Zhang - Bioengineering, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is the most common and serious type of primary liver
cancer. HCC patients have a high death rate and poor prognosis due to the lack of clear …

SP1-mediated up-regulation of lncRNA TUG1 underlines an oncogenic property in colorectal cancer

W Liu, J Meng, R Su, C Shen, S Zhang, Y Zhao… - Cell death & …, 2022 - nature.com
The long non-coding RNA (lncRNA) taurine up-regulated gene 1 (TUG1) acts as tumor-
promoting factor in colorectal cancer (CRC). We aimed to elucidate the mechanism by which …

Serum‐Based lncRNA ANRIL, TUG1, UCA1, and HIT Expressions in Breast Cancer Patients

AG Alkhathami, A Hadi, M Alfaifi… - Disease …, 2022 - Wiley Online Library
Breast cancer is a heterogeneous disease and is the most common and prevalent form of
malignancy diagnosed in women. lncRNAs are found to be frequently dysregulated in …