SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …

Biology of lung macrophages in health and disease

H Aegerter, BN Lambrecht, CV Jakubzick - Immunity, 2022 - cell.com
Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …

The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19

C Schultheiß, E Willscher, L Paschold, C Gottschick… - Cell Reports …, 2022 - cell.com
Post-acute sequelae of COVID-19 (PASC) is emerging as global problem with unknown
molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to …

Immune response in COVID-19: what is next?

Q Li, Y Wang, Q Sun, J Knopf, M Herrmann… - Cell Death & …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

F Karagiannis, K Peukert, L Surace, M Michla… - Nature, 2022 - nature.com
Anorexia and fasting are host adaptations to acute infection, and induce a metabolic switch
towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate …

Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19

P Laurent, C Yang, AF Rendeiro… - Science …, 2022 - science.org
Lung-infiltrating macrophages create a marked inflammatory milieu in a subset of patients
with COVID-19 by producing a cytokine storm, which correlates with increased lethality …

The good and the bad: Monocytes' and macrophages' diverse functions in inflammation

J Austermann, J Roth, K Barczyk-Kahlert - Cells, 2022 - mdpi.com
Monocytes and macrophages are central players of the innate immune response and play a
pivotal role in the regulation of inflammation. Thereby, they actively participate in all phases …

Recent advances in regenerative biomaterials

D Cao, J Ding - Regenerative Biomaterials, 2022 - academic.oup.com
Nowadays, biomaterials have evolved from the inert supports or functional substitutes to the
bioactive materials able to trigger or promote the regenerative potential of tissues. The …

[HTML][HTML] Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model

Z Pei, Y Qin, X Fu, F Yang, F Huo, X Liang, S Wang… - Redox biology, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by
excessive proliferation of fibroblasts and excessive accumulation of extracellular matrix …

Long-term outcomes of pediatric infections: from traditional infectious diseases to long Covid

D Buonsenso, LD Gennaro, CD Rose… - Future …, 2022 - Taylor & Francis
There is limited evidence available on the long-term impact of SARS-CoV-2 infection in
children. In this article, the authors analyze the recent evidence on pediatric long Covid and …