Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Pulmonary surfactant is a complex lipoprotein mixture secreted into the alveolar lumen by
type 2 pneumocytes, which is composed by tens of different lipids (approximately 90% of its …

Autoimmune pulmonary alveolar proteinosis (PAP) is a rare disease characterized by
myeloid cell dysfunction, abnormal pulmonary surfactant accumulation, and innate immune …

Alveolar macrophages (AM) hold lung homeostasis intact. In addition to the defense against
inhaled pathogens and deleterious inflammation, AM also maintain pulmonary surfactant …

Background. Pulmonary alveolar proteinosis (PAP) is a rare disorder which is characterized
by the accumulation of excessive surfactant lipids and proteins in alveolar macrophages and …

Menin is necessary for the formation of the menin/mixed lineage leukemia (MLL) complex
and is recruited directly to chromatin. Menin is an important tumor suppressor in several …

Background Pulmonary alveolar proteinosis (PAP) is a rare syndrome first described by
Rosen et al. in 1958. Despite our considerably evolved understanding of PAP over the past …

Background High-resolution computed tomography (HRCT) plays an important role in
accessing the severity of pulmonary alveolar proteinosis (PAP). Visual evaluation of …

We read with great interest the article “Methionine supplementation for multi-organ
dysfunction in MetRS-related pulmonary alveolar proteinosis” by Hadchouel et al [1]. The …

Pulmonary alveolar proteinosis (PAP) is a diffuse lung disease characterized by the
accumulation of alveolar surfactants due to dysfunction of granulocyte-macrophage colony …