Pharmacological effects of cannabidiol by transient receptor potential channels

L Etemad, G Karimi, MS Alavi, A Roohbakhsh - Life Sciences, 2022 - Elsevier
Cannabidiol (CBD), as a major phytocannabinoid of Cannabis sativa, has emerged as a
promising natural compound in the treatment of diseases. Its diverse pharmacological …

[HTML][HTML] Cannabinoids as medicinals

JH Khalsa, G Bunt, K Blum, SB Maggirwar… - Current addiction …, 2022 - Springer
Purpose of review There have been many debates, discussions, and published writings
about the therapeutic value of cannabis plant and the hundreds of cannabinoids it contains …

Clinical management of cannabis withdrawal

JP Connor, D Stjepanović, AJ Budney, B Le Foll… - …, 2022 - Wiley Online Library
Abstract Background and Aims Cannabis withdrawal is a well‐characterized phenomenon
that occurs in approximately half of regular and dependent cannabis users after abrupt …

[HTML][HTML] Cannabis for Medical Use: Versatile Plant Rather Than a Single Drug

S Procaccia, GM Lewitus, C Lipson Feder… - Frontiers in …, 2022 - frontiersin.org
Medical Cannabis and its major cannabinoids (−)-trans-Δ9-tetrahydrocannabinol (THC) and
cannabidiol (CBD) are gaining momentum for various medical purposes as their therapeutic …

Synthetic Strategies for Rare Cannabinoids Derived from Cannabis sativa

GN Nguyen, EN Jordan, O Kayser - Journal of natural products, 2022 - ACS Publications
Efficient syntheses of eight key cannabinoids were established and optimized. Predominant
cannabinoids such as cannabigerol (CBG-C5) and cannabidiol (CBD-C5) were prepared …

Statement on safety of cannabidiol as a novel food: data gaps and uncertainties

EFSA Panel on Nutrition, Novel Foods and Food … - EFSA …, 2022 - Wiley Online Library
Abstract The European Commission has determined that cannabidiol (CBD) can be
considered as a novel food (NF), and currently, 19 applications are under assessment at …

[HTML][HTML] Cannabis sativa and skin health: Dissecting the role of phytocannabinoids

G Martinelli, A Magnavacca, M Fumagalli… - Planta …, 2022 - thieme-connect.com
The use of Cannabis sativa is currently recognized to ease certain types of chronic pain,
reduce chemotherapy-induced nausea, and improve anxiety. Nevertheless, few studies …

[HTML][HTML] Cannabidiol interacts antagonistically with cisplatin and additively with mitoxantrone in various melanoma cell lines—An isobolographic analysis

P Marzęda, P Wróblewska-Łuczka, M Drozd… - International Journal of …, 2022 - mdpi.com
The medical application of cannabidiol (CBD) has been gathering increasing attention in
recent years. This non-psychotropic cannabis-derived compound possesses antiepileptic …

[HTML][HTML] Minor phytocannabinoids: A misleading name but a promising opportunity for biomedical research

D Caprioglio, HIM Amin, O Taglialatela-Scafati… - Biomolecules, 2022 - mdpi.com
Despite the very large number of phytocannabinoids isolated from Cannabis (Cannabis
sativa L.), bioactivity studies have long remained focused on the so called “Big Four”[Δ9 …

[HTML][HTML] Antimicrobial and cytotoxic effects of cannabinoids: an updated review with future perspectives and current challenges

MA Saleemi, N Yahaya, NNM Zain, M Raoov, YK Yong… - Pharmaceuticals, 2022 - mdpi.com
The development of new antibiotics is urgently needed to combat the threat of bacterial
resistance. New classes of compounds that have novel properties are urgently needed for …