[HTML][HTML] Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer's disease and normal physiology
Alzheimer's disease (AD) is an incurable neurodegenerative disorder in which dysfunction
and loss of synapses and neurons lead to cognitive impairment and death. Accumulation …
and loss of synapses and neurons lead to cognitive impairment and death. Accumulation …
[HTML][HTML] Aβ profiles generated by Alzheimer's disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset
D Petit, SG Fernández, KM Zoltowska, T Enzlein… - Molecular …, 2022 - nature.com
Familial Alzheimer's disease (FAD), caused by mutations in Presenilin (PSEN1/2) and
Amyloid Precursor Protein (APP) genes, is associated with an early age at onset (AAO) of …
Amyloid Precursor Protein (APP) genes, is associated with an early age at onset (AAO) of …
[HTML][HTML] Oligomer formation by amyloid-β42 in a membrane-mimicking environment in alzheimer's disease
The brains of Alzheimer's disease (AD) patients contain numerous amyloid plaques that are
diagnostic of the disease. The plaques are primarily composed of the amyloidogenic …
diagnostic of the disease. The plaques are primarily composed of the amyloidogenic …
[HTML][HTML] Influence of sleep disruption on protein accumulation in neurodegenerative diseases
X Wang, R Wang, J Li - Ageing and Neurodegenerative Diseases, 2022 - oaepublish.com
Abnormal accumulation of disease proteins in the central nervous system is a
neuropathological feature in neurodegenerative disorders. Recently, a growing body of …
neuropathological feature in neurodegenerative disorders. Recently, a growing body of …
Lysosomal dysfunction in Down Syndrome and Alzheimer mouse models is caused by selective v-ATPase inhibition by Tyr682 phosphorylated APP βCTF
Lysosome dysfunction arises early and propels Alzheimer's Disease (AD). Herein, we show
that amyloid precursor protein (APP), linked to early-onset AD in Down Syndrome (DS), acts …
that amyloid precursor protein (APP), linked to early-onset AD in Down Syndrome (DS), acts …
[HTML][HTML] Clinical characteristics and genotype-phenotype correlation analysis of familial Alzheimer's disease patients with pathogenic/likely pathogenic amyloid protein …
Y Liu, X Xiao, H Liu, X Liao, Y Zhou, L Weng… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with
aging, environmental, and genetic factors. Amyloid protein precursor (APP) is a known …
aging, environmental, and genetic factors. Amyloid protein precursor (APP) is a known …
[HTML][HTML] Identification of the Third Case of PSEN1 Tyr389His Variant in Early-Onset Alzheimer's Disease in Korea
KH Shim, S Kang, SSA An, MJ Kang - International Journal of Molecular …, 2022 - mdpi.com
Amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2) are
associated with autosomal-dominant early-onset Alzheimer's disease (AD). Most mutations …
associated with autosomal-dominant early-onset Alzheimer's disease (AD). Most mutations …
Mechanistic regulation of γ-secretase by their substrates
JL Velasco-Bolom, L Domínguez - Physical Chemistry Chemical …, 2022 - pubs.rsc.org
γ-Secretase (GS) is a transmembrane (TM) enzyme that plays important roles in the
processing of approximately 90 substrates. The amyloid precursor protein (APP) is one of …
processing of approximately 90 substrates. The amyloid precursor protein (APP) is one of …
[HTML][HTML] Covalent fragment inhibits intramembrane proteolysis
A Eden, J Zhao, Y Xiao, J Gibson… - Frontiers in Molecular …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a serious public health crisis with only one current modifying
treatment. The reduction of amyloid load by targeting γ-secretase (GS) has been a leading …
treatment. The reduction of amyloid load by targeting γ-secretase (GS) has been a leading …
Development and application of a high-throughput biophysical approach to study transmembrane protein interactions with small molecules
MA Castro - 2022 - search.proquest.com
Alzheimer's disease (AD) is the most common form of dementia in the US with no disease-
modifying therapies. A key hallmark of AD is the generation of amyloid-β (Aβ) peptides and …
modifying therapies. A key hallmark of AD is the generation of amyloid-β (Aβ) peptides and …