Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or
cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in …

PTEN is among the most commonly lost or mutated tumor suppressor genes in human
cancer. PTEN, a bona fide lipid phosphatase that antagonizes the highly oncogenic PI3K …

As an important post-translational modification, ubiquitination mediates∼ 80% of protein
degradation in eukaryotes. The degree of protein ubiquitination is tightly determined by the …

Aberrant self-renewal of leukemia initiation cells (LICs) drives aggressive acute myeloid
leukemia (AML). Here, we report that UHRF1, an epigenetic regulator that recruits DNMT1 to …

Dysregulation of kinase signaling pathways favors tumor cell survival and therapy resistance
in cancer. Here, we reveal a posttranslational regulation of kinase signaling and nuclear …

Ubiquitination is a critical biological process in post-translational modification of proteins
and involves multiple signaling pathways in protein metabolism, apoptosis, DNA damage …

Ubiquitination is one of the most crucial ways of protein degradation and plays an
indispensable role in various living activities of cells. The deubiquitinating enzyme (DUB) is …

Ubiquitin specific protease USP15 is a deubiquitinating enzyme reported to regulate several
biological and cellular processes, including TGF-β signaling, regulation of immune …

NZ754139A - Novel peptides and combination of peptides for use in immunotherapy against
ovarian cancer and other cancers - Google Patents NZ754139A - Novel peptides and …

The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the …