Small round cell sarcomas

F Cidre-Aranaz, S Watson, JF Amatruda… - Nature Reviews …, 2022 - nature.com
Undifferentiated small round cell sarcomas (SRCSs) of bone and soft tissue comprise a
heterogeneous group of highly aggressive tumours associated with a poor prognosis …

Polycomb-dependent histone H2A ubiquitination links developmental disorders with cancer

S Tamburri, E Conway, D Pasini - Trends in Genetics, 2022 - cell.com
Cell identity is tightly controlled by specific transcriptional programs which require post-
translational modifications of histones. These histone modifications allow the establishment …

MicroRNA-196a-5p overexpression in Wharton's jelly umbilical cord stem cells promotes their osteogenic differentiation and new bone formation in bone defects in the …

Y Wang, S Zhang, H Yang, Y Cao, D Yu, Y Zhao… - Cell and Tissue …, 2022 - Springer
The peri-tooth root alveolar loss often does not have sufficient space for repair material
transplantation and plasticity. Mesenchymal stem cell (MSC) sheets have an advantage in …

[HTML][HTML] Epigenetics and congenital heart diseases

L Linglart, D Bonnet - Journal of Cardiovascular Development and …, 2022 - mdpi.com
Congenital heart disease (CHD) is a frequent occurrence, with a prevalence rate of almost
1% in the general population. However, the pathophysiology of the anomalous heart …

Epigenetic regulation of methylation in determining the fate of dental mesenchymal stem cells

H Zhang, H Fu, H Fang, Q Deng, H Huang… - Stem Cells …, 2022 - Wiley Online Library
Dental mesenchymal stem cells (DMSCs) are crucial in tooth development and periodontal
health, and their multipotential differentiation and self‐renewal ability play a critical role in …

[HTML][HTML] Molecular mechanism of hyperactive tooth root formation in oculo-facio-cardio-dental syndrome

K Min Soe, T Ogawa, K Moriyama - Frontiers in Physiology, 2022 - frontiersin.org
Mutations in the B-cell lymphoma 6 (BCL6) interacting corepressor (BCOR) cause oculo-
facio-cardio-dental (OFCD) syndrome, a rare X-linked dominant condition that includes …

[HTML][HTML] DNA Hypermethylation and a Specific Methylation Spectrum on the X Chromosome in Turner Syndrome as Determined by Nanopore Sequencing

X Fan, B Zhang, L Fan, J Chen, C Su, B Cao… - Journal of Personalized …, 2022 - mdpi.com
The molecular genetic mechanism of Turner syndrome (TS) still leaves much to be
discovered. Methods: TS (45X0) patients and age-matched controls (46XX and 46XY) were …

Nonsyndromic Generalized Radiculomegaly of Permanent Dentition: A Rare Case Report

M Alhussain, N Almosa, H Alnofaie - Case Reports in Dentistry, 2022 - Wiley Online Library
Introduction. Radiculomegaly (marked elongation of dental roots) is a distinct dental
abnormality with a major clinical significance that is closely related to oculofaciocardiodental …

Markers for bone sarcomas

M Tallegas, A Gomez-Brouchet, M Legrand… - Bone Sarcomas and …, 2022 - Elsevier
The classification of bone sarcomas is still today mainly based on the comparison of
histological, clinical, and radiological criteria. This classification evolves with the …

Interplay between Polycomb PCGF protein interactomes revealed by screening under endogenous conditions

N Munawar, K Wynne, G Oliviero - bioRxiv, 2022 - biorxiv.org
The six PCGF proteins (PCGF1-6) define the biochemical identity of Polycomb Repressor
Complex 1 (PRC1) subcomplexes. While structural and functional studies of PRC1 …