Peptide therapeutics have recently gained momentum in antiviral therapy due to their
increased potency and cost-effectiveness. Interaction of the HIV-1 envelope gp120 with the …

The development of peptide-based HIV entry inhibitors has made an important contribution
to the stock of anti-HIV drugs. In particular, the peptide-based anti-HIV drugs enfuvirtide and …

This article outlines the design and development of scyllatoxin (ScTx)–based BH3 domain
mimetics with diverse patterns of native disulfide bonds. More specifically, this method …

Protein-protein interactions (PPIs) have emerged as promising targets for PPI modulators as
alternative drugs because they are essential for most biochemical processes in living …

Viruses are disease-causing pathogenic agents that require host cells to replicate. Fusion of
host and viral membranes is critical for the lifecycle of enveloped viruses. Studying viral …

-80-based vaccine immunogen capable of inducing immunity against all circulating HIV-1
groups and clades. To address viral diversity, researchers have tried to design immunogens …

Event-driven pharmacology is a new paradigm in disease treatment for a wide range of
diseases, including cancer, that have failed by traditional occupancy-driven pharmacology …

Apoptosis is a form of controlled cell death that occurs as a normal part of an organism's
growth and development. Apoptosis is often initiated as a result of external or internal …

Inhibitor cysteine knots (ICKs), called'knottins', are linear cysteine knot peptides, usually
composed of approximately 30 amino acids having characteristic sturdy structure consistent …