Pathogenic enteric viruses are a major cause of morbidity and mortality, particularly among
children in developing countries. The host response to enteric viruses occurs primarily within …

A cornerstone of the global initiative to eradicate polio is the widespread use of live and
inactivated poliovirus vaccines in extensive public health campaigns designed to prevent …

Background A longitudinal study was performed to determine the breadth, kinetics, and
correlations of systemic and mucosal antibody responses to severe acute respiratory …

Eradication of poliomyelitis globally is constrained by fecal shedding of live polioviruses,
both wild-type and vaccine-derived strains, into the environment. Although inactivated polio …

Background Primary intestinal immunity through viral replication of live oral vaccine is key to
interrupt poliovirus transmission. We assessed viral fecal shedding from infants …

Emergence of mutations is an inherent property of RNA viruses with several implications for
their replication, pathogenesis, and evolutionary adaptation. Oral poliovirus vaccine (OPV) …

In a blinded phase 1 trial (EudraCT 2017-0000908-21; NCT03430349) in Belgium, healthy
adults (aged 18–50 years) previously immunized exclusively with inactivated poliovirus …

Although vaccination against SARS-CoV-2 has substantially reduced severe disease, there
have been many milder breakthrough infections. One possible explanation for these …

Background: Sabin inactivated and bivalent oral poliovirus vaccine (sIPV, bOPV) were
commonly used in China since 2016. We conducted a continuous open-label, randomised …