Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system
S Gritsch, TT Batchelor, LN Gonzalez Castro - Cancer, 2022 - Wiley Online Library
The 2016 revised fourth edition of the World Health Organization (WHO) classification of
central nervous system (CNS) tumors incorporated molecular features with histologic …
central nervous system (CNS) tumors incorporated molecular features with histologic …
Therapeutic and prognostic insights from the analysis of cancer mutational signatures
The somatic mutations in each cancer genome are caused by multiple mutational
processes, each of which leaves a characteristic imprint (or 'signature'), potentially caused …
processes, each of which leaves a characteristic imprint (or 'signature'), potentially caused …
Glioma progression is shaped by genetic evolution and microenvironment interactions
The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify
treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …
treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …
Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities
The molecular events and transcriptional plasticity driving brain metastasis in clinically
relevant breast tumor subtypes has not been determined. Here we comprehensively dissect …
relevant breast tumor subtypes has not been determined. Here we comprehensively dissect …
[HTML][HTML] Polarization of tumor-associated macrophages by TLR7/8 conjugated radiosensitive peptide hydrogel for overcoming tumor radioresistance
Radioresistance reduces the antitumor efficiency of radiotherapy and further restricts its
clinical application, which is mainly caused by the aggravation of immunosuppressive tumor …
clinical application, which is mainly caused by the aggravation of immunosuppressive tumor …
Therapy sculpts the complex interplay between cancer and the immune system during tumour evolution
K Thol, P Pawlik, N McGranahan - Genome Medicine, 2022 - Springer
Cancer development is an evolutionary process. A key selection pressure is exerted by
therapy, one of the few players in cancer evolution that can be controlled. As such, an …
therapy, one of the few players in cancer evolution that can be controlled. As such, an …
Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features
Cancers of unknown primary (CUP) origin account for∼ 3% of all cancer diagnoses,
whereby the tumor tissue of origin (TOO) cannot be determined. Using a uniformly …
whereby the tumor tissue of origin (TOO) cannot be determined. Using a uniformly …
A radiologist's guide to the 2021 WHO Central Nervous System Tumor Classification: part I—key concepts and the spectrum of diffuse gliomas
DR Johnson, C Giannini, RA Vaubel, JM Morris… - Radiology, 2022 - pubs.rsna.org
The fifth edition of the World Health Organization (WHO) classification of tumors of the
central nervous system, published in 2021, contains substantial updates in the classification …
central nervous system, published in 2021, contains substantial updates in the classification …
Preoperative diagnosis and molecular characterization of gliomas with liquid biopsy and radiogenomics
C Balana, S Castañer, C Carrato, T Moran… - Frontiers in …, 2022 - frontiersin.org
Gliomas are a heterogenous group of central nervous system tumors with different outcomes
and different therapeutic needs. Glioblastoma, the most common subtype in adults, has a …
and different therapeutic needs. Glioblastoma, the most common subtype in adults, has a …
Salmonella as a Promising Curative Tool against Cancer
RP Aganja, C Sivasankar, A Senevirathne, JH Lee - Pharmaceutics, 2022 - mdpi.com
Bacteria-mediated cancer therapy has become a topic of interest under the broad umbrella
of oncotherapy. Among many bacterial species, Salmonella remains at the forefront due to …
of oncotherapy. Among many bacterial species, Salmonella remains at the forefront due to …