Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

The Wnt pathway is involved in several processes essential for bone development and
homeostasis. For proper functioning, the Wnt pathway is tightly regulated by numerous …

Activation of Wnt signaling leads to high bone density. The R-spondin family of four secreted
glycoproteins (Rspo1-4) amplifies Wnt signaling. In humans, RSPO3 variants are strongly …

Context Many different inherited and acquired conditions can result in premature bone
fragility/low bone mass disorders (LBMDs). Objective We aimed to elucidate the impact of …

This population-based study investigated the association between depression and bone
mineral density (BMD), fractures, and osteoporosis in the US population. We found that …

Osteoporosis is the most prevalent bone condition in the ageing population. This systemic
disease is characterized by microarchitectural deterioration of bone, leading to increased …

Surgical menopause (iatrogenic menopause) happens when both ovaries are removed
before the natural “switching off” of ovarian function; it can cause premature ovarian …

Aim To describe the presenting features, bone characteristics and molecular genetics in a
large monocentric cohort of children and young adults with idiopathic primary osteoporosis …

Osteoporosis usually alters the chemical composition and physical microstructure of bone.
Currently, most clinical techniques for bone assessment are focused on the either bone …

Background Genetic factors play a critical role in the pathogenesis of osteoporosis. The
imbalance of WNT/β-catenin will cause the occurrence of osteoporosis. LRP5 and AXIN1 …