Millions of people suffer from arthritis worldwide, consistently struggling with daily activities
due to debilitating pain evoked by this disease. Perhaps the most intensively investigated …

Microglia are resident macrophages of the brain, performing roles related to brain
homeostasis, including modulation of synapses, trophic support, phagocytosis of apoptotic …

Nociception is a fundamental acute protective mechanism that prevents harm to an
organism. Understanding the integral processes that control nociceptive processing are …

Tumor necrosis factor receptor-associated factor 6 (TRAF6) has been reported to be
expressed in spinal astrocytes and is involved in neuropathic pain. In this study, we …

The insular cortex (IC) is known to process pain information. However, analgesic effects of
glial inhibition in the IC have not yet been explored. The aim of this study was to investigate …

临床上脊髓损伤对国家, 社会和个人产生重大身体, 心理和经济负担. 脊髓损伤后,
血脑屏障被破坏, 血细胞渗入损伤部位, 神经元和胶质细胞发生死亡, 进而引起受损轴突的脱髓鞘 …

Chronic pain is a disease affecting 1 in 5 Canadians1 and the leading cause of disability
worldwide2. Among the most debilitating forms of chronic pain is neuropathic pain, which is …

The goal of this study is to examine mechanisms underlying cortical reorganization in rat
primary somatosensory (SI) cortex that follows forelimb deafferentation. The majority of …

Chronic pain is a significant health care issue affecting over 100 million Americans with
musculoskeletal pain prevalent in 13-47% of the population. Musculoskeletal pain …

The goal of this study is to examine mechanisms underlying cortical reorganization in rat
primary somatosensory (SI) cortex that follows forelimb deafferentation. The majority of …