Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review
S Uyttebroek, B Chen, J Onsea… - The Lancet Infectious …, 2022 - thelancet.com
According to the latest reports from WHO, the incidence of antibiotic-resistant bacterial
infections is increasing worldwide, resulting in increased morbidity and mortality and a rising …
infections is increasing worldwide, resulting in increased morbidity and mortality and a rising …
Considerations for the use of phage therapy in clinical practice
Increasing antimicrobial resistance and medical device-related infections have led to a
renewed interest in phage therapy as an alternative or adjunct to conventional …
renewed interest in phage therapy as an alternative or adjunct to conventional …
Biomaterial-based antimicrobial therapies for the treatment of bacterial infections
PP Kalelkar, M Riddick, AJ García - Nature Reviews Materials, 2022 - nature.com
The rise in antibiotic-resistant bacteria, including strains that are resistant to last-resort
antibiotics, and the limited ability of antibiotics to eradicate biofilms have necessitated the …
antibiotics, and the limited ability of antibiotics to eradicate biofilms have necessitated the …
Novel antimicrobial agents for combating antibiotic-resistant bacteria
Antibiotic therapy has become increasingly ineffective against bacterial infections due to the
rise of resistance. In particular, ESKAPE pathogens (Enterococcus faecium, Staphylococcus …
rise of resistance. In particular, ESKAPE pathogens (Enterococcus faecium, Staphylococcus …
Mutualistic interplay between bacteriophages and bacteria in the human gut
Bacteriophages (phages) are often described as obligate predators of their bacterial hosts,
and phage predation is one of the leading forces controlling the density and distribution of …
and phage predation is one of the leading forces controlling the density and distribution of …
Antibiotic discovery and resistance: the chase and the race
The history of antimicrobial resistance (AMR) evolution and the diversity of the
environmental resistome indicate that AMR is an ancient natural phenomenon. Acquired …
environmental resistome indicate that AMR is an ancient natural phenomenon. Acquired …
Catheter-associated urinary tract infections: current challenges and future prospects
GT Werneburg - Research and reports in urology, 2022 - Taylor & Francis
Catheter-associated urinary tract infection (CAUTI) is the most common healthcare-
associated infection and cause of secondary bloodstream infections. Despite many …
associated infection and cause of secondary bloodstream infections. Despite many …
The safety and efficacy of phage therapy: a systematic review of clinical and safety trials
HJ Stacey, S De Soir, JD Jones - Antibiotics, 2022 - mdpi.com
Trials of phage therapy have not consistently reported efficacy. This contrasts with promising
efficacy rates from a sizeable and compelling body of observational literature. This …
efficacy rates from a sizeable and compelling body of observational literature. This …
Recent progress toward the implementation of phage therapy in Western medicine
JP Pirnay, T Ferry, G Resch - FEMS microbiology reviews, 2022 - academic.oup.com
Like the sword of Damocles, the threat of a post-antibiotic era is hanging over humanity's
head. The scientific and medical community is thus reconsidering bacteriophage therapy …
head. The scientific and medical community is thus reconsidering bacteriophage therapy …
Parallel evolution of Pseudomonas aeruginosa phage resistance and virulence loss in response to phage treatment in vivo and in vitro
With rising antibiotic resistance, there has been increasing interest in treating pathogenic
bacteria with bacteriophages (phage therapy). One limitation of phage therapy is the ease at …
bacteria with bacteriophages (phage therapy). One limitation of phage therapy is the ease at …