Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review

S Uyttebroek, B Chen, J Onsea… - The Lancet Infectious …, 2022 - thelancet.com
According to the latest reports from WHO, the incidence of antibiotic-resistant bacterial
infections is increasing worldwide, resulting in increased morbidity and mortality and a rising …

Considerations for the use of phage therapy in clinical practice

GA Suh, TP Lodise, PD Tamma… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Increasing antimicrobial resistance and medical device-related infections have led to a
renewed interest in phage therapy as an alternative or adjunct to conventional …

Biomaterial-based antimicrobial therapies for the treatment of bacterial infections

PP Kalelkar, M Riddick, AJ García - Nature Reviews Materials, 2022 - nature.com
The rise in antibiotic-resistant bacteria, including strains that are resistant to last-resort
antibiotics, and the limited ability of antibiotics to eradicate biofilms have necessitated the …

Novel antimicrobial agents for combating antibiotic-resistant bacteria

RYK Chang, SC Nang, HK Chan, J Li - Advanced drug delivery reviews, 2022 - Elsevier
Antibiotic therapy has become increasingly ineffective against bacterial infections due to the
rise of resistance. In particular, ESKAPE pathogens (Enterococcus faecium, Staphylococcus …

Mutualistic interplay between bacteriophages and bacteria in the human gut

AN Shkoporov, CJ Turkington, C Hill - Nature Reviews Microbiology, 2022 - nature.com
Bacteriophages (phages) are often described as obligate predators of their bacterial hosts,
and phage predation is one of the leading forces controlling the density and distribution of …

Antibiotic discovery and resistance: the chase and the race

K Iskandar, J Murugaiyan, D Hammoudi Halat… - Antibiotics, 2022 - mdpi.com
The history of antimicrobial resistance (AMR) evolution and the diversity of the
environmental resistome indicate that AMR is an ancient natural phenomenon. Acquired …

Catheter-associated urinary tract infections: current challenges and future prospects

GT Werneburg - Research and reports in urology, 2022 - Taylor & Francis
Catheter-associated urinary tract infection (CAUTI) is the most common healthcare-
associated infection and cause of secondary bloodstream infections. Despite many …

The safety and efficacy of phage therapy: a systematic review of clinical and safety trials

HJ Stacey, S De Soir, JD Jones - Antibiotics, 2022 - mdpi.com
Trials of phage therapy have not consistently reported efficacy. This contrasts with promising
efficacy rates from a sizeable and compelling body of observational literature. This …

Recent progress toward the implementation of phage therapy in Western medicine

JP Pirnay, T Ferry, G Resch - FEMS microbiology reviews, 2022 - academic.oup.com
Like the sword of Damocles, the threat of a post-antibiotic era is hanging over humanity's
head. The scientific and medical community is thus reconsidering bacteriophage therapy …

Parallel evolution of Pseudomonas aeruginosa phage resistance and virulence loss in response to phage treatment in vivo and in vitro

M Castledine, D Padfield, P Sierocinski, JS Pascual… - Elife, 2022 - elifesciences.org
With rising antibiotic resistance, there has been increasing interest in treating pathogenic
bacteria with bacteriophages (phage therapy). One limitation of phage therapy is the ease at …