PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression

L Sui, S Wang, D Ganguly, TP El Rayes… - Nature …, 2022 - nature.com
The progression of cancer from localized to metastatic disease is the primary cause of
morbidity and mortality. The interplay between the tumor and its microenvironment is the key …

IL4 stimulated macrophages promote axon regeneration after peripheral nerve injury by secreting uPA to stimulate uPAR upregulated in injured axons

Y Matsui, K Kadoya, Y Nagano, T Endo, M Hara… - Cellular and Molecular …, 2022 - Springer
Accumulating evidences suggest that M2 macrophages are involved with repair processes
in the nervous system. However, whether M2 macrophages can promote axon regeneration …

The uPA/uPAR system in astrocytic wound healing

M Yepes - Neural Regeneration Research, 2022 - journals.lww.com
The repair of injured tissue is a highly complex process that involves cell proliferation,
differentiation, and migration. Cell migration requires the dismantling of intercellular contacts …

[HTML][HTML] Review of evidence implicating the plasminogen activator system in blood-brain barrier dysfunction associated with Alzheimer's disease

MY Tang, FA Gorin, PJ Lein - Ageing and neurodegenerative …, 2022 - ncbi.nlm.nih.gov
Elucidating the pathogenic mechanisms of Alzheimer's disease (AD) to identify therapeutic
targets has been the focus of many decades of research. While deposition of extracellular …

Bone marrow stromal cells attenuate oxygen and glucose deprivation followed by re‑oxygenation‑induced brain microvascular endothelial cell injury

CN Fang, T Song, X Tao, SF Liu, Z Feng - Acta Neurobiologiae …, 2022 - ane.pl
Ischemic stroke is a severe threat to the health of older individuals. Bone marrow
mesenchymal stem cells (BMSCs) have been implicated in ischemic stroke. Urokinase‑type …

Urokinase-Type Plasminogen Activator Triggers Wingless/Int1-Independent Phosphorylation of the Low-Density Lipoprotein Receptor-Related Protein-6 in Cerebral …

A Diaz, C Martin-Jimenez, Y Woo… - Journal of …, 2022 - content.iospress.com
Background: Urokinase-type plasminogen activator (uPA) is a serine proteinase found in
excitatory synapses located in the II/III and V cortical layers. The synaptic release of uPA …

星形胶质细胞伤口愈合中的uPA/uPAR 系统

M Yepes - 中国神经再生研究(英文版), 2022 - sjzsyj.com.cn
The repair of injured tissue is a highly complex process that involves cell proliferation,
differentiation, and migration. Cell migration requires the dismantling of intercellular contacts …

Simulated in vitro hypoxic conditions from psoriatic arthritis cartilage change plasminogen activating system urokinase and serpine functionality. Reversal of …

M Nohawica, A Nowak-Terpilowska… - … in Dermatology and …, 2022 - termedia.pl
Simulated in vitro hypoxic conditions from psoriatic arthritis cartilage change plasminogen
activating system urokinase and serp Page 1 Advances in Dermatology and Allergology 5 …

Anomalías neuronales en la esquizofrenia: Ampliando la mirada desde la perspectiva de nicho

DC Garrido Jara - 2022 - repositorio.uchile.cl
La esquizofrenia es un trastorno psiquiátrico cuyo origen, la evidencia apunta, se remonta
al neurodesarrollo. Durante el proceso embrionario el sistema vascular y nervioso se …

[HTML][HTML] Изменение содержания рецептора урокиназы и других компонентов фибринолитической системы в ткани мозга у мышей с нокаутом гена урокиназы …

ЕМ Франциянц, ВА Бандовкина… - Research'n Practical …, 2022 - cyberleninka.ru
Цель исследования. Изучить изменение содержания компонентов урокиназной
системы в мозге у мышей с нокаутом урокиназы (uPA-/-) в случае самостоятельного и …