Patient-important outcomes other than mortality in contemporary ICU trials: a scoping review

A Granholm, CT Anthon, MBN Kjær… - Critical Care …, 2022 - journals.lww.com
OBJECTIVES: Randomized clinical trials (RCTs) conducted in adult ICU patients
increasingly include patient-important outcomes other than mortality. This comes with …

Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia

A Granholm, MBN Kjær, MW Munch, SN Myatra… - Intensive care …, 2022 - Springer
Purpose We assessed long-term outcomes of dexamethasone 12 mg versus 6 mg given
daily for up to 10 days in patients with coronavirus disease 2019 (COVID-19) and severe …

Cognitive Outcomes in the Pragmatic Investigation of optimaL Oxygen Targets (CO-PILOT) trial: protocol and statistical analysis plan

MF Mart, MW Semler, G Bernard, JD Casey, EW Ely… - BMJ open, 2022 - bmjopen.bmj.com
Introduction Long-term cognitive impairment is one of the most common complications of
critical illness among survivors who receive mechanical ventilation. Recommended oxygen …

Missing data in palliative care research: estimands and estimators

J Roydhouse, L Floden, S Braat, A Grobler… - BMJ supportive & …, 2022 - spcare.bmj.com
There are several methodological challenges when conducting randomised controlled trials
in palliative care. These include worsening function and high mortality, leading to treatment …

Health‐related quality of life and days alive without life support or out of hospital: Protocol

A Granholm, OL Schjørring, AKG Jensen… - Acta …, 2022 - Wiley Online Library
Background Mortality is often the primary outcome in randomised clinical trials (RCTs)
conducted in critically ill patients. Due to increased awareness on survivors after critical …