Therapeutic interventions to mitigate mitochondrial dysfunction and oxidative stress–induced damage in patients with bipolar disorder

S Madireddy, S Madireddy - International Journal of Molecular Sciences, 2022 - mdpi.com
Bipolar disorder (BD) is characterized by mood changes, including recurrent manic,
hypomanic, and depressive episodes, which may involve mixed symptoms. Despite the …

Brain–immune interaction mechanisms: Implications for cognitive dysfunction in psychiatric disorders

F Zhao, B Li, W Yang, T Ge, R Cui - Cell Proliferation, 2022 - Wiley Online Library
Objectives Cognitive dysfunction has been identified as a major symptom of a series of
psychiatric disorders. Multidisciplinary studies have shown that cognitive dysfunction is …

[HTML][HTML] Fluoxetine shows neuroprotective effects against LPS-induced neuroinflammation via the Notch signaling pathway

J Zhang, N Zhang, J Lei, B Jing, M Li, H Tian… - International …, 2022 - Elsevier
Aim To determine the neuroprotective effects of fluoxetine on depression-like and motor
behaviors in rats treated with lipopolysaccharide (LPS) and the mechanisms involved …

Pathophysiology of depression: stingless bee honey promising as an antidepressant

FH Zakaria, I Samhani, MZ Mustafa, N Shafin - Molecules, 2022 - mdpi.com
Depression is a debilitating psychiatric disorder impacting an individual's quality of life. It is
the most prevalent mental illness across all age categories, incurring huge socio-economic …

Immunoinflammatory processes: Overlapping mechanisms between obesity and eating disorders?

E Breton, JF Soh, L Booij - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Obesity and eating disorders are conditions that involve eating behaviors and are
sometimes comorbid. Current evidence supports alterations in immunoinflammatory …

LPS activates neuroinflammatory pathways to induce depression in Parkinson's disease-like condition

J Zhang, B Xue, B Jing, H Tian, N Zhang, M Li… - Frontiers in …, 2022 - frontiersin.org
Aim: This study aimed to observe the effects of lipopolysaccharide (LPS) intraperitoneal (ip)
injection on rats and investigate how neuroinflammation contributes to the pathogenesis of …

Immune–Inflammatory Biomarkers Predict Cognition and Social Functioning in Patients With Type 2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder …

M Garés-Caballer, JV Sánchez-Ortí… - Frontiers in …, 2022 - frontiersin.org
Background Systemic, low-grade immune–inflammatory activity, together with social and
neurocognitive performance deficits are a transdiagnostic trait of people suffering from type …

[HTML][HTML] Associations between heart rate variability, peripheral inflammatory markers and major depressive disorder

A Buchmann, C Ritter, ST Müller, M Haynes… - Journal of affective …, 2022 - Elsevier
Background: Measures for the irregularity of the heartbeat, for example respiratory sinus
arrhythmia, have been implicated as a measure for restorative functions of the vegetative …

Effect of low-dose statins in addition to standard therapy on brain perfusion and neurocognitive performance in patients with major depressive disorder

T Massardo, JC Quintana, L Risco, S Corral… - …, 2022 - karger.com
Introduction: Major depressive disorder (MDD) is a prevalent condition which has a well-
known association with ischemic cardiomyopathy, probably explained by an inflammatory …

Treatment-induced mood switching in affective disorders

SW Tang, WH Tang, BE Leonard - Acta Neuropsychiatrica, 2022 - cambridge.org
Many patients under treatment for mood disorders, in particular patients with bipolar mood
disorders, experience episodes of mood switching from one state to another. Various …