Proteolysis-targeting chimeras (PROTACs) have emerged as effective tools to selectively
degrade disease-related proteins by using the ubiquitin-proteasome system. Developing …

Fine particles are in great demand in the pharmaceutical industry due to their versatile
applications. Liquid antisolvent crystallization (LASC) is one of the promising approaches to …

As a drug advances through the late stages of clinical development, formulation changes
are common to meet clinical, manufacturing, and/or business needs. Since some formulation …

Purpose Surfactants are increasingly being added to amorphous solid dispersion (ASDs)
formulations to enhance processability and release performance. The goal of the current …

Cocrystal engineering for bioavailability enhancement is still a serendipitous process, which
requires systematic solution crystallization, in vivo predictive dissolution, and …

Multi-drug resistant (MDR) Salmonella enterica Enteritidis is one of the major causes of
foodborne illnesses worldwide. This non-typhoidal Salmonella (NTS) serovar is mainly …

To elucidate the critical parameters affecting drug dissolution in the human stomach, the
intrinsic dissolution rate (IDR) of cinnarizine was determined in aspirated and simulated …

The present study investigated the oral bioavailability of celecoxib when incorporated into
solid lipid nanoparticles either dissolved or suspended. In vitro drug release in different …

Food-mediated changes to drug absorption, termed the food effect, are hard to predict and
can have significant implications for the safety and efficacy of oral drug products in patients …

Introduction Biopredictive release tests are commonly used in the evaluation of oral
medicines. They support decision-making in formulation development and allow predictions …