Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …

Numerous evidence indicates that inflammation in adipose tissue is the primary cause of
systemic insulin resistance induced by obesity. Obesity-associated changes in circulating …

Background A comprehensive understanding of the molecular mechanisms of adipogenesis
is a critically important strategy for identifying new targets for obesity intervention. Methods …

Phosphoglycerate dehydrogenase (PHGDH) is a key serine biosynthesis enzyme whose
aberrant expression promotes various types of tumors. Recently, PHGDH has been found to …

The prevalence of obesity and its associated pathologies continue to increase, which has
led to a renewed interest in our major weight‐regulating organ, the white adipose tissue. It …

Adipocytes can increase in volume up to a thousand-fold, storing excess calories as
triacylglycerol in large lipid droplets. The dramatic morphological changes required of …

Atherosclerosis is a chronic multifactorial cardiovascular disease. Western diets have been
reported to affect atherosclerosis through regulating adipose function. In high cholesterol …

DNA N6-adenine methylation (6mA), as a novel adenine modification existing in eukaryotes,
shows essential functions in embryogenesis and mitochondrial transcriptions. ALKBH1 is a …

It is well-established that adipose tissue accumulation is associated with insulin resistance
through multiple mechanisms. One major metabolic link is the classical Randle cycle …