Promising strategy for developing mRNA-based universal influenza virus vaccine for human population, poultry, and pigs–focus on the bigger picture

N Rcheulishvili, D Papukashvili, C Liu, Y Ji… - Frontiers in …, 2022 - frontiersin.org
Since the first outbreak in the 19th century influenza virus has remained emergent owing to
the huge pandemic potential. Only the pandemic of 1918 caused more deaths than any war …

Next generation live-attenuated influenza vaccine platforms

S Ullah, TM Ross - Expert Review of Vaccines, 2022 - Taylor & Francis
Introduction Influenza virus is a major cause of seasonal epidemics and intermittent
pandemics. Despite the current molecular biology and vaccine development, influenza virus …

Review of genome sequencing technologies in molecular characterization of influenza A viruses in swine

RP Chauhan, ML Gordon - Journal of Veterinary Diagnostic …, 2022 - journals.sagepub.com
The rapidly evolving antigenic diversity of influenza A virus (IAV) genomes in swine makes it
imperative to detect emerging novel strains and track their circulation. We analyzed in our …

Pathobiology of an NS1-truncated H3N2 swine influenza virus strain in pigs

E Vandoorn, W Stadejek, A Parys… - Journal of …, 2022 - Am Soc Microbiol
Virus strains in the live attenuated influenza vaccine (LAIV) for swine in the United States
that was on the market until 2020 encode a truncated nonstructural protein 1 of 126 amino …

Live attenuated influenza A virus vaccines with modified NS1 proteins for veterinary use

A Nogales, ML DeDiego… - Frontiers in cellular and …, 2022 - frontiersin.org
Influenza A viruses (IAV) spread rapidly and can infect a broad range of avian or mammalian
species, having a tremendous impact in human and animal health and the global economy …

Immunogenicity and protective efficacy of A recombinant pichinde viral-vectored vaccine expressing influenza virus hemagglutinin antigen in pigs

S Kumari, J Chaudhari, Q Huang, P Gauger… - Vaccines, 2022 - mdpi.com
Influenza A virus of swine (IAV-S) is an economically important swine pathogen. The IAV-S
hemagglutinin (HA) surface protein is the main target for vaccine development. In this study …

Evaluating α-galactosylceramide as an adjuvant for live attenuated influenza vaccines in pigs

BL Artiaga, I Morozov, R Ransburgh, T Kwon… - Animal Diseases, 2022 - Springer
Natural killer T (NKT) cells activated with the glycolipid ligand α-galactosylceramide (α-
GalCer) stimulate a wide variety of immune cells that enhance vaccine-mediated immune …

[HTML][HTML] Efficacy of the NS1-truncated live attenuated influenza virus vaccine for swine against infection with viruses of major north American and European H3N2 …

E Vandoorn, A Parys, S Chepkwony, K Chiers… - Vaccine, 2022 - Elsevier
Control of swine influenza A virus (swIAV) in North America and Europe is complicated
because multiple antigenically distinct swIAV strains co-circulate in the field, and no vaccine …

Study towards the development of broadly reactive live attenuated influenza vaccines with focus on high interferon inducing viral subpopulations

A Ghorbani - 2022 - rave.ohiolink.edu
Influenza A virus (IAV) continues to pose an enormous threat to animal and public health
owing to the emergence of novel strains with panzootic and pandemic potential. Effective …

Respiratory immunisation and mucosal immunity against influenza

V Martini - 2022 - ora.ox.ac.uk
Influenza A virus (IAV) is a considerable threat to human and animal health. Current
immunisation strategies rely primarily on inducing strain-specific neutralising antibodies with …