[HTML][HTML] Mass spectrometry imaging in drug distribution and drug metabolism studies–Principles, applications and perspectives
JR Granborg, AM Handler, C Janfelt - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
New mass spectrometry imaging (MSI) techniques are gaining importance in various stages
of the drug discovery and development chain as well as in more fundamental studies of drug …
of the drug discovery and development chain as well as in more fundamental studies of drug …
Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging
ML Spruill, M Maletic-Savatic, H Martin, F Li… - Biochemical …, 2022 - Elsevier
Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …
High resolution ambient MS imaging of biological samples by desorption electro-flow focussing ionization
In this study, we examine the suitability of desorption electro-flow focusing ionization (DEFFI)
for mass spectrometry imaging (MSI) of biological tissue. We also compare the performance …
for mass spectrometry imaging (MSI) of biological tissue. We also compare the performance …
Evaluation of formalin-fixed and FFPE tissues for spatially resolved metabolomics and drug distribution studies
A Dannhorn, JG Swales, G Hamm, N Strittmatter… - Pharmaceuticals, 2022 - mdpi.com
Fixation of samples is broadly used prior to the histological evaluation of tissue samples.
Though recent reports demonstrated the ability to use fixed tissues for mass spectrometry …
Though recent reports demonstrated the ability to use fixed tissues for mass spectrometry …
[HTML][HTML] A temporo-spatial pharmacometabolomics method to characterize pharmacokinetics and pharmacodynamics in the brain microregions by using ambient …
D Liu, J Huang, S Gao, H Jin, J He - Acta Pharmaceutica Sinica B, 2022 - Elsevier
The brain is the most advanced organ with various complex structural and functional
microregions. It is often challenging to understand what and where the molecular events …
microregions. It is often challenging to understand what and where the molecular events …
Atmospheric-pressure infrared laser-ablation plasma-postionization mass spectrometry imaging of formalin-fixed paraffin-embedded (FFPE) and fresh-frozen tissue …
RT Steven, M Niehaus, AJ Taylor, A Nasif… - Analytical …, 2022 - ACS Publications
Mass spectrometry imaging (MSI) encompasses a powerful suit of techniques which provide
spatially resolved atomic and molecular information from almost any sample type. MSI is …
spatially resolved atomic and molecular information from almost any sample type. MSI is …
Distribution visualization of the chlorinated disinfection byproduct of diazepam in zebrafish with desorption electrospray ionization mass spectrometry imaging
X Zhao, X Huang, X Zhang, J Shi, X Jia, K Zhu, B Shao - Talanta, 2022 - Elsevier
Diazepam (DZP) was routinely prescribed to a large population troubled with anxiety
disorders. However, due to the overuse and misuse, DZP and its chlorination disinfection …
disorders. However, due to the overuse and misuse, DZP and its chlorination disinfection …
Detection and characterization of simvastatin and its metabolites in rat tissues and biological fluids using MALDI high resolution mass spectrometry approach
Simvastatin (SV) is a hypolipidemic agent, and it is the 2nd most widely prescribed lipid-
lowering drug. Here, the detection and characterization of SV and its metabolites was …
lowering drug. Here, the detection and characterization of SV and its metabolites was …
Correlating mass spectrometry imaging and liquid chromatography-tandem mass spectrometry for tissue-based pharmacokinetic studies
A Dannhorn, E Kazanc, G Hamm, JG Swales… - Metabolites, 2022 - mdpi.com
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a standard tool used for
absolute quantification of drugs in pharmacokinetic (PK) studies. However, all spatial …
absolute quantification of drugs in pharmacokinetic (PK) studies. However, all spatial …