Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …

Inflammasomes are multiprotein complexes that can sense danger signals and activate
caspase-1 to mediate pro-inflammatory cytokines release and pyroptotic cell death. There …

Nonalcoholic steatohepatitis (NASH) is a liver disease associated with significant morbidity.
Kupffer cells (KCs) produce endogenous miR-690 and, via exosome secretion, shuttle this …

With recent progress in modeling liver organogenesis and regeneration, the lack of
vasculature is becoming the bottleneck in progressing our ability to model human hepatic …

The nonnegligible reason for the poor prognosis of hepatocellular carcinoma (HCC) is
resistance to conventional chemotherapy. Immunogenic cell death (ICD) is a rare …

The regenerative function of liver can be destroyed by viral infection, drug poisoning and
tumorigenesis, resulting in irreversible damage. Numerous approaches in promoting liver …

In nature, cells reside in tissues subject to complex cell–cell interactions, signals from
extracellular molecules and niche soluble and mechanical signaling. These …

We are entering an era of medicine where increasingly sophisticated data will be obtained
from patients to determine proper diagnosis, predict outcomes and direct therapies. We …

The extracellular matrix (ECM) mechanical properties regulate key cellular processes in
tissue development and regeneration. The majority of scientific investigation has focused on …

The extracellular matrix plays a critical role in bioinstructing cellular self‐assembly and
spatial (re) configuration processes that culminate in human organoids in vitro generation …