Drug delivery to the central nervous system

E Nance, SH Pun, R Saigal, DL Sellers - Nature Reviews Materials, 2022 - nature.com
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

Progression in translational research on spinal cord injury based on microenvironment imbalance

B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

High drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury

W Li, J Chen, S Zhao, T Huang, H Ying… - Nature …, 2022 - nature.com
Drug delivery systems with high content of drug can minimize excipients administration,
reduce side effects, improve therapeutic efficacy and/or promote patient compliance …

Molecular mechanisms and clinical application of multipotent stem cells for spinal cord injury

M Szymoniuk, J Litak, L Sakwa, A Dryla, W Zezuliński… - Cells, 2022 - mdpi.com
Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …

Management of acute spinal cord injury: Where have we been? Where are we now? Where are we going?

MG Fehlings, K Pedro, N Hejrati - Journal of Neurotrauma, 2022 - liebertpub.com
The strides that have been achieved in the realm of spinal cord injury (SCI) management are
remarkable. It is likely that 90% of what has been recognized to date about SCI …

Elevated intraspinal pressure in traumatic spinal cord injury is a promising therapeutic target

CH Yang, ZX Quan, GJ Wang, T He… - Neural Regeneration …, 2022 - journals.lww.com
The currently recommended management for acute traumatic spinal cord injury aims to
reduce the incidence of secondary injury and promote functional recovery. Elevated …

A bibliometric analysis of publications on spinal cord injury treatment with glucocorticoids using VOSviewer

Y Zhang, AA Li, SN Xiao, NS Zhong, WL Tong… - Frontiers in Public …, 2022 - frontiersin.org
Background Spinal cord injury (SCI) has devastating physical and social consequences for
patients. Systemic administration of methylprednisolone (MP) at a higher dosage though can …

Current treatments after spinal cord injury: Cell engineering, tissue engineering, and combined therapies

Y Shen, X Cao, M Lu, H Gu, M Li, DA Posner - Smart Medicine, 2022 - Wiley Online Library
Both traumatic and non‐traumatic spinal cord injuries (SCIs) can be categorized as
damages done to our central nervous system (CNS). The patients' physical and mental …

Developing novel therapies for degenerative cervical myelopathy [AO spine RECODE-DCM research priority number 7]: opportunities from restorative neurobiology

AA Gharooni, BK Kwon, MG Fehlings… - Global spine …, 2022 - journals.sagepub.com
Study design Narrative review. Objectives To provide an overview of contemporary
therapies for the James Lind Alliance priority setting partnership for degenerative cervical …

Acute traumatic spinal cord injury

EC Taylor, CE Fitzpatrick, SE Thompson… - Advanced emergency …, 2022 - journals.lww.com
Approximately 17,000 new spinal cord injuries occur each year in the United States, with
motor vehicle collisions and falls being the most common causes. Even though 94% of …