Drug delivery to the central nervous system
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …
development remains challenging, with high costs, long pathways to clinical use and high …
Progression in translational research on spinal cord injury based on microenvironment imbalance
B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …
and imposes a considerable burden on patients, families, and society. Repair of the injured …
High drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury
W Li, J Chen, S Zhao, T Huang, H Ying… - Nature …, 2022 - nature.com
Drug delivery systems with high content of drug can minimize excipients administration,
reduce side effects, improve therapeutic efficacy and/or promote patient compliance …
reduce side effects, improve therapeutic efficacy and/or promote patient compliance …
Molecular mechanisms and clinical application of multipotent stem cells for spinal cord injury
M Szymoniuk, J Litak, L Sakwa, A Dryla, W Zezuliński… - Cells, 2022 - mdpi.com
Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …
Management of acute spinal cord injury: Where have we been? Where are we now? Where are we going?
The strides that have been achieved in the realm of spinal cord injury (SCI) management are
remarkable. It is likely that 90% of what has been recognized to date about SCI …
remarkable. It is likely that 90% of what has been recognized to date about SCI …
Elevated intraspinal pressure in traumatic spinal cord injury is a promising therapeutic target
CH Yang, ZX Quan, GJ Wang, T He… - Neural Regeneration …, 2022 - journals.lww.com
The currently recommended management for acute traumatic spinal cord injury aims to
reduce the incidence of secondary injury and promote functional recovery. Elevated …
reduce the incidence of secondary injury and promote functional recovery. Elevated …
A bibliometric analysis of publications on spinal cord injury treatment with glucocorticoids using VOSviewer
Y Zhang, AA Li, SN Xiao, NS Zhong, WL Tong… - Frontiers in Public …, 2022 - frontiersin.org
Background Spinal cord injury (SCI) has devastating physical and social consequences for
patients. Systemic administration of methylprednisolone (MP) at a higher dosage though can …
patients. Systemic administration of methylprednisolone (MP) at a higher dosage though can …
Current treatments after spinal cord injury: Cell engineering, tissue engineering, and combined therapies
Both traumatic and non‐traumatic spinal cord injuries (SCIs) can be categorized as
damages done to our central nervous system (CNS). The patients' physical and mental …
damages done to our central nervous system (CNS). The patients' physical and mental …
Developing novel therapies for degenerative cervical myelopathy [AO spine RECODE-DCM research priority number 7]: opportunities from restorative neurobiology
AA Gharooni, BK Kwon, MG Fehlings… - Global spine …, 2022 - journals.sagepub.com
Study design Narrative review. Objectives To provide an overview of contemporary
therapies for the James Lind Alliance priority setting partnership for degenerative cervical …
therapies for the James Lind Alliance priority setting partnership for degenerative cervical …
Acute traumatic spinal cord injury
EC Taylor, CE Fitzpatrick, SE Thompson… - Advanced emergency …, 2022 - journals.lww.com
Approximately 17,000 new spinal cord injuries occur each year in the United States, with
motor vehicle collisions and falls being the most common causes. Even though 94% of …
motor vehicle collisions and falls being the most common causes. Even though 94% of …