Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

Gene transfer using adeno-associated viral (AAV) vectors has made tremendous progress in
the last decade and has achieved cures of debilitating diseases such as hemophilia A and …

Immunological memory is a hallmark of adaptive immunity and facilitates an accelerated and
enhanced immune response upon re-infection with the same pathogen,. Since the outbreak …

Vaccination affords protection from disease by activating pathogen-specific immune cells
and facilitating the development of persistent immunologic memory toward the vaccine …

Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

Tumor Treating Fields (TTFields), an approved therapy for glioblastoma (GBM) and
malignant mesothelioma, employ noninvasive application of low-intensity, intermediate …

Spermidine (SPD) delays age-related pathologies in various organisms. SPD
supplementation overcame the impaired immunotherapy against tumors in aged mice by …

The mechanistic/mammalian target of rapamycin (mTOR) is a downstream mediator in the
phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways, which plays a pivotal role in …

Immune checkpoint inhibitors (ICIs) have revolutionized the clinical management of multiple
tumours. However, only a few patients respond to ICIs, which has generated considerable …

Nutrition affects all physiological processes including those linked to the development and
function of our immune system. Here, we discuss recent evidence and emerging concepts …