The role of oxidative stress and inflammation in X-link adrenoleukodystrophy
J Yu, T Chen, X Guo, MI Zafar, H Li, Z Wang… - Frontiers in …, 2022 - frontiersin.org
X-linked adrenoleukodystrophy (X-ALD) is an inherited disease caused by a mutation in the
ABCD1 gene encoding a peroxisomal transmembrane protein. It is characterized by the …
ABCD1 gene encoding a peroxisomal transmembrane protein. It is characterized by the …
Activating cannabinoid receptor 2 preserves axonal health through GSK-3β/NRF2 axis in adrenoleukodystrophy
Aberrant endocannabinoid signaling accompanies several neurodegenerative disorders,
including multiple sclerosis. Here, we report altered endocannabinoid signaling in X-linked …
including multiple sclerosis. Here, we report altered endocannabinoid signaling in X-linked …
Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model
Aims Mitochondrial dysfunction and inflammation are at the core of axonal degeneration in
several multifactorial neurodegenerative diseases, including multiple sclerosis, Alzheimer's …
several multifactorial neurodegenerative diseases, including multiple sclerosis, Alzheimer's …
Therapeutic potential of deuterium‐stabilized (R)‐pioglitazone—PXL065—for X‐linked adrenoleukodystrophy
PA Monternier, J Singh, P Parasar… - Journal of inherited …, 2022 - Wiley Online Library
X‐linked adrenoleukodystrophy (ALD) results from ABCD1 gene mutations which impair
Very Long Chain Fatty Acids (VLCFA; C26: 0 and C24: 0) peroxisomal import and β …
Very Long Chain Fatty Acids (VLCFA; C26: 0 and C24: 0) peroxisomal import and β …
Translational and clinical pharmacology considerations in drug repurposing for X‐linked adrenoleukodystrophy—A rare peroxisomal disorder
X‐linked adrenoleukodystrophy (X‐ALD) is an inherited, neurodegenerative rare disease
that can result in devastating symptoms of blindness, gait disturbances and spastic …
that can result in devastating symptoms of blindness, gait disturbances and spastic …
Beneficial effects of the direct AMP-kinase activator PXL770 in in vitro and in vivo models of X-linked adrenoleukodystrophy
PA Monternier, P Parasar, P Theurey, PG Dagorn… - … of Pharmacology and …, 2022 - ASPET
X-linked adrenoleukodystrophy (ALD) is a severe orphan disease caused by mutations in
the peroxisomal ABCD1 transporter gene, leading to toxic accumulation of Very Long-Chain …
the peroxisomal ABCD1 transporter gene, leading to toxic accumulation of Very Long-Chain …
The clinical spectrum of X-linked adrenoleukodystrophy: from Addison's-only in men to middle-age neurologic manifestations in women
L Fadiga, M Melo, J Saraiva, I Paiva - Hormones, 2022 - Springer
Abstract X-linked adrenoleukodystrophy (X-ALD) is caused by a mutation in the ABCD1
gene which encodes for a peroxisomal very long-chain fatty acid (VLCFA) transporter …
gene which encodes for a peroxisomal very long-chain fatty acid (VLCFA) transporter …
Pharmaceutical compositions comprising the PPAR agonist INT-131 and Nrf2 activators
BC Kahrs - US Patent 11,484,530, 2022 - Google Patents
The invention relates to pharmaceutical compositions comprising PPAR agonists and Nrf2
activators and methods of using combinations of PPAR agonists and Nrf2 activators for …
activators and methods of using combinations of PPAR agonists and Nrf2 activators for …