Mechanism of RNA recognition by a Musashi RNA-binding protein
The Musashi RNA-binding proteins (RBPs) regulate translation of target mRNAs and
maintenance of cell stemness and tumorigenesis. Musashi-1 (MSI1), long considered as an …
maintenance of cell stemness and tumorigenesis. Musashi-1 (MSI1), long considered as an …
GLOW: A workflow integrating Gaussian-accelerated molecular dynamics and deep learning for free energy profiling
We introduce a Gaussian-accelerated molecular dynamics (GaMD), deep learning (DL), and
free energy profiling workflow (GLOW) to predict molecular determinants and map free …
free energy profiling workflow (GLOW) to predict molecular determinants and map free …
Protein–protein interaction-Gaussian accelerated molecular dynamics (PPI-GaMD): Characterization of protein binding thermodynamics and kinetics
Protein–protein interactions (PPIs) play key roles in many fundamental biological processes
such as cellular signaling and immune responses. However, it has proven challenging to …
such as cellular signaling and immune responses. However, it has proven challenging to …
Gaussian accelerated molecular dynamics in OpenMM
Gaussian accelerated molecular dynamics (GaMD) is a computational technique that
provides both unconstrained enhanced sampling and free energy calculations of …
provides both unconstrained enhanced sampling and free energy calculations of …
PNC-27, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis
E Sarafraz-Yazdi, S Mumin, D Cheung, D Fridman… - Biomedicines, 2022 - mdpi.com
PNC-27, a 32-residue peptide that contains an HDM-2 binding domain and a cell-
penetrating peptide (CPP) leader sequence kills cancer, but not normal, cells by binding to …
penetrating peptide (CPP) leader sequence kills cancer, but not normal, cells by binding to …