Abstract Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with
crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic …

Introduction Dupilumab is a human monoclonal antibody that targets both IL-4 and IL-13
signaling. It is currently indicated for the treatment of asthma, moderate-to-severe atopic …

Clonal hematopoiesis arises from somatic mutations that provide a fitness advantage to
hematopoietic stem cells and the outgrowth of clones of blood cells. Clonal hematopoiesis …

Background & Aims Beyond the classical description of eosinophil functions in parasite
infections and allergic diseases, emerging evidence supports a critical role of eosinophils in …

Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting
receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure …

T helper type 2 cells (Th2 cells) and group 2 innate lymphoid cells (ILC2s) play an important
role in the pathophysiology of asthma, including airway eosinophilic inflammation. ILC2s are …

Background: SH2B3 (SH2B adaptor protein 3) is an adaptor protein that negatively
regulates cytokine signaling and cell proliferation. A common missense single nucleotide …

We develop a scalable and highly efficient algorithm to fit a Cox proportional hazard model
by maximizing the-regularized (Lasso) partial likelihood function, based on the Batch …

Background The distribution and determinants of blood eosinophil counts in the general
population are unclear. Furthermore, whether elevated blood eosinophil counts increase …

The influence of gut microbiota on host immunity is widely studied, and its disturbance has
been linked to several immune-mediated disorders. Conversely, whether and how …