Aging represents the single greatest risk factor for chronic diseases, including osteoporosis,
a skeletal fragility syndrome that increases fracture risk. Optimizing bone strength throughout …

Recently, the increasing prevalence of diabetes mellitus has made it a major chronic illness
which poses a substantial threat to human health. The prevalence of osteoporosis among …

Diabetes-associated bone complications lead to fragile bone mechanical strength and
osteoporosis, aggravating the disease burden of patients. Advanced evidence shows that …

Mesenchymal stem cells (MSCs) are the most promising multipotent stem cells that can
differentiate into osteoblasts, chondrocytes, and adipocytes. This cellular flexibility …

Abstract Glucocorticoid (GC)-induced osteoporosis (GIOP) is the most common type of
secondary osteoporosis. Osteoblast apoptosis induced by GCs is now considered as a …

Introduction Patients with haemophilia (PWH) have a high prevalence of osteoporosis, falls
and fractures at all ages. The role of haemophilia itself may contribute to low bone mineral …

Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of antidiabetic
drugs, acting by inhibiting the reabsorption of glucose in the kidneys. They turned out to …

Objective In men, many effects of testosterone (T) on the skeleton are thought to be
mediated by estradiol (E2), but trial evidence is largely lacking. This study aimed to …

Bone development have been shown to play an important role in regulating hematopoiesis
as one major component of bone marrow microenvironment. Recent studies support the …

Vitamin D helps to balance the levels of calcium and phosphorus to maintain proper bone
structure. It is also involved in essential biological roles and displays a wide spectrum of …