Importance Clinicians, patients, and policy makers rely on published results from clinical
trials to help make evidence-informed decisions. To critically evaluate and use trial results …

Big data is important to new developments in global clinical science that aim to improve the
lives of patients. Technological advances have led to the regular use of structured electronic …

Background & Aims Artificial intelligence-based computer-aided polyp detection (CADe)
systems are intended to address the issue of missed polyps during colonoscopy. The effect …

Background Depression is a common mental health condition that affects 1 in 8 males each
year, especially young adults. Young adulthood offers an opportunity for early dietary …

Results from clinical trials can be deemed trustworthy only if they are properly conducted
and their methods are fully reported. The SPIRIT and CONSORT checklists, which have …

Importance Complete information in a trial protocol regarding study outcomes is crucial for
obtaining regulatory approvals, ensuring standardized trial conduct, reducing research …

Objectives To review evidence about the uptake of core outcome sets (COS). A COS is an
agreed standardized set of outcomes that should be measured and reported, as a minimum …

Background Complex regional pain syndrome (CRPS) is a painful and disabling condition
that usually manifests in response to trauma or surgery and is associated with significant …

A history of safe use is a backbone of safety assessments for many current probiotic species,
however, there is no global harmonization regarding requirements for establishing probiotic …

Background Systematic reviews of outcome measurement instruments are important tools in
the evidence-based selection of these instruments. COSMIN (COnsensus-based Standards …