Antioxidant therapies in traumatic brain injury

CK Davis, R Vemuganti - Neurochemistry International, 2022 - Elsevier
Oxidative stress plays a crucial role in traumatic brain injury (TBI) pathogenesis. Reactive
oxygen species (ROS) and reactive nitrogen species (RNS) formed in excess after TBI …

Diet-microbiome-gut-brain nexus in acute and chronic brain injury

MA Krakovski, N Arora, S Jain, J Glover… - Frontiers in …, 2022 - frontiersin.org
In recent years, appreciation for the gut microbiome and its relationship to human health has
emerged as a facilitator of maintaining healthy physiology and a contributor to numerous …

Possible involvement of female sex steroid hormones in intracellular signal transduction mediated by cytokines following traumatic brain injury

F Farahani, M Khaksari, S Amiresmaili, M Iranpour… - Brain research …, 2022 - Elsevier
Introduction The aim of this study was to determine the anti-inflammatory effect of female sex
hormones on the level of intracellular molecules of cytokine signaling pathway after diffuse …

Mild-to-severe traumatic brain injury in children: altered cytokines reflect severity

E Ryan, L Kelly, C Stacey, D Huggard, E Duff… - Journal of …, 2022 - Springer
Background Paediatric traumatic brain injury (TBI) is recognised to have significant longer-
term neurocognitive effects. Childhood is a time of high risk for head injury. Functional …

[HTML][HTML] Comparing imaging biomarkers of cerebral edema after TBI in young adult male and female rats

HM Minchew, SL Ferren, SK Christian, J Hu… - Brain research, 2022 - Elsevier
Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide.
Cerebral edema following TBI is known to play a critical role in injury severity and prognosis …

Effects of progesterone on preclinical animal models of traumatic brain injury: Systematic review and meta-analysis

RG Nasre-Nasser, MMR Severo, GN Pires… - Molecular …, 2022 - Springer
Since the publication of two phase III clinical trials not supporting the use of progesterone in
patients with traumatic brain injury (TBI), several possible explanations have been …

[HTML][HTML] Gender discrepancy in patients with traumatic brain injury: a retrospective study from a Level 1 trauma center

A El-Menyar, A Mekkodathil, V Verma… - BioMed research …, 2022 - hindawi.com
Objectives. The objective of this study is to explore the gender discrepancy in patients with
traumatic brain injury (TBI). Methods. A retrospective analysis of Qatar Trauma Registry …

Does Vitamin D Administration Increase the Neuroprotective Effect of Estrogen in Male Rats with Traumatic Brain Injury?

A Alinaghi Langari, N Sabet, H Bashiri… - Journal of Kerman …, 2022 - jkmu.kmu.ac.ir
Background: In our previous studies, the effect of sex hormones on brain edema reduction
after traumatic brain injury (TBI) was demonstrated. In the current study, alone and combined …

The outcome of severely injured patients following traumatic brain injury is affected by gender—A retrospective, multicenter, matched-pair analysis utilizing data of the …

O Mair, F Greve, R Lefering, P Biberthaler… - Frontiers in …, 2022 - frontiersin.org
Introduction Traumatic brain injury (TBI) causes a major health-concern globally. Gender-
dependent differences in mortality outcome after TBI have been controversially discussed …

Raised intracranial pressure and tissue compliance after large intracerebral hemorrhages in animal models and patients

CM Wilkinson - 2022 - era.library.ualberta.ca
Brain injuries that cause mass effect, including stroke and traumatic brain injury, can
increase intracranial pressure (ICP) due to the limited space within the skull. Intracerebral …