[HTML][HTML] PAK-dependent regulation of actin dynamics in breast cancer cells
M Best, ME Gale, CM Wells - The international journal of biochemistry & …, 2022 - Elsevier
Abstract Metastatic Breast Cancer has a poor 25% survival rate and currently there are no
clinical therapeutics which target metastasis.'Migrastatics' are a new drug class which target …
clinical therapeutics which target metastasis.'Migrastatics' are a new drug class which target …
The Wnt/β-catenin pathway in breast cancer therapy: a pre-clinical perspective of its targeting for clinical translation
Introduction Despite various treatments available, there is still a high mortality rate in breast
cancer patients. Thus, there exists an unmet need for new therapeutic interventions. Studies …
cancer patients. Thus, there exists an unmet need for new therapeutic interventions. Studies …
Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/PAK1/MMP-2 signaling …
YY Yi, H Chen, SB Zhang, HW Xu, XY Fang… - Mechanisms of Ageing …, 2022 - Elsevier
Intervertebral disc degeneration (IDD) is highly ubiquitous in the aged population and is an
essential factor for low back pain and spinal disability. Because of the association between …
essential factor for low back pain and spinal disability. Because of the association between …
[HTML][HTML] EIF4A3-induced circBRWD3 promotes tumorigenesis of breast cancer through miR-142-3p_miR-142-5p/RAC1/PAK1 signaling
X Meng, W Li, Z Meng, Y Li - BMC cancer, 2022 - Springer
CircBRWD3 is a newly discovered circRNA, and its potential function has not been probed.
Here, we aimed to molecularly dissect the role of circBRWD3 in the tumorigenesis and …
Here, we aimed to molecularly dissect the role of circBRWD3 in the tumorigenesis and …
Diindolylmethane Promotes Metabolic Crisis and Enhances the Efficacy of Centchroman in Breast Cancer: A 1H NMR-Based Approach
Diindolylmethane (DIM) is a key metabolite of indole-3-carbinol found in cruciferous
vegetables such as broccoli, cauliflower, and cabbage. DIM has been known for its anti …
vegetables such as broccoli, cauliflower, and cabbage. DIM has been known for its anti …
The Development of Inhibitors to Target the Driving Functions of PAK1 in Cancer
D Harbaugh - FAU Undergraduate Research Journal, 2022 - journals.flvc.org
The p21-activated kinases (PAKs) are a family of protein kinases that play major roles as
downstream effectors of the small G-proteins Cdc42 and Rac1 under normal physiological …
downstream effectors of the small G-proteins Cdc42 and Rac1 under normal physiological …