Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens
RA Quinlan, JI Clark - Journal of Biological Chemistry, 2022 - ASBMB
In the human eye, a transparent cornea and lens combine to form the" refracton" to focus
images on the retina. This requires the refracton to have a high refractive index" n," mediated …
images on the retina. This requires the refracton to have a high refractive index" n," mediated …
Insight into the mammalian aquaporin interactome
S Törnroth-Horsefield, C Chivasso… - International journal of …, 2022 - mdpi.com
Aquaporins (AQPs) are a family of transmembrane water channels expressed in all living
organisms. AQPs facilitate osmotically driven water flux across biological membranes and …
organisms. AQPs facilitate osmotically driven water flux across biological membranes and …
Beyond the channels: adhesion functions of aquaporin 0 and connexin 50 in lens development
Z Li, Y Quan, S Gu, JX Jiang - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Lens, an avascular tissue involved in light transmission, generates an internal
microcirculatory system to promote ion and fluid circulation, thus providing nutrients to …
microcirculatory system to promote ion and fluid circulation, thus providing nutrients to …
Arvcf dependent adherens junction stability is required to prevent age-related cortical cataracts
JB Martin, K Herman, NS Houssin, W Rich… - Frontiers in Cell and …, 2022 - frontiersin.org
The etiology of age-related cortical cataracts is not well understood but is speculated to be
related to alterations in cell adhesion and/or the changing mechanical stresses occurring in …
related to alterations in cell adhesion and/or the changing mechanical stresses occurring in …
Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation
PJ Minogue, JJ Tong, K Wichmann, H Mysliwiec… - Journal of Biological …, 2022 - ASBMB
Many human connexin50 (Cx50) mutants have been linked to cataracts including two
carboxyl terminus serine mutants that are known phosphorylation sites in the lens …
carboxyl terminus serine mutants that are known phosphorylation sites in the lens …
[HTML][HTML] The miRNA-34a/Sirt1/p53 pathway in a rat model of lens regeneration
X Bi, R Wang, H Song, Y Wang, P Hao… - Annals of Translational …, 2022 - ncbi.nlm.nih.gov
Background There are many molecular factors involved in Wolffian and corneal lens
regeneration, but few in lens regeneration by lens epithelial cells (LECs) in mammals. Silent …
regeneration, but few in lens regeneration by lens epithelial cells (LECs) in mammals. Silent …
[HTML][HTML] Studying macrophage activation in immune-privileged lens through CSF-1 protein intravitreal injection in mouse model
Macrophage (MΦ) activation and promotion of fibrosis are critical processes in lens capsule
healing after injury. Here, we detail a protocol that induces MΦ2 formation within the vitreous …
healing after injury. Here, we detail a protocol that induces MΦ2 formation within the vitreous …