Obesity and cancer—extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases

NS Pellegata, M Berriel Diaz, M Rohm… - Cancer and Metastasis …, 2022 - Springer
Obesity is an established risk factor for several human cancers. Given the association
between excess body weight and cancer, the increasing rates of obesity worldwide are …

Neural component of the tumor microenvironment in pancreatic ductal adenocarcinoma

M Gola, A Sejda, J Godlewski, M Cieślak, A Starzyńska - Cancers, 2022 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal
cancers worldwide, with a poor prognosis and an increasing incidence. Recently, the tumor …

The effect of beta adrenoreceptor blockers on viability and cell colony formation of non-small cell lung cancer cell lines A549 and H1299

M Sidorova, V Petrikaitė - Molecules, 2022 - mdpi.com
Beta adrenoblockers are a large class of drugs used to treat cardiovascular diseases,
migraines, glaucoma and hyperthyroidism. Over the last couple of decades, the anticancer …

NNK from tobacco smoking enhances pancreatic cancer cell stemness and chemoresistance by creating a β2AR‐Akt feedback loop that activates autophagy

X Chen, W Zhang, R Liu, Z Zhu, M Gong… - Molecular …, 2022 - Wiley Online Library
Low responsiveness to chemotherapy is an important cause of poor prognosis in pancreatic
cancer. Smoking is a high‐risk factor for pancreatic cancer and cancer resistance to …

Effect of chronic stress on tumorigenesis and development

C Wang, Y Shen, J Ni, W Hu, Y Yang - Cellular and Molecular Life …, 2022 - Springer
Chronic stress activates the sympathetic nervous system (SNS) and hypothalamic–pituitary–
adrenal (HPA) axis to aggravates tumorigenesis and development. Although the importance …

Dissecting the role of cell signaling versus CD8+ T cell modulation in propranolol antitumor activity

W Li, J Wan, C Chen, C Zhou, P Liao, Q Hu… - Journal of Molecular …, 2022 - Springer
Preclinical and early clinical mechanistic studies of antitumor activity from the beta-
adrenergic receptor (β-AR) blocker propranolol have revealed both cell signaling and …

Anti-tumoral effect of beta-blockers on prostate and bladder cancer cells via mitogen-activated protein kinase pathways

S Özler, P Pazarci - Anti-Cancer Drugs, 2022 - journals.lww.com
The incidence of prostate cancer in the world is increasing every year. Death caused by
prostate cancer is increased by 13% in men between 1980 and 2005. It is the second …

[HTML][HTML] An update on common pharmaceuticals in the prevention of pancreatic cancer

C Miyaki, LM Lynch - Cureus, 2022 - ncbi.nlm.nih.gov
In this review, we aim to update readers about the most recent studies on common
pharmaceuticals and their association with pancreatic cancer risk. The use of prophylactic …

Beta adrenergic blockade and clinical outcomes in patients with colorectal cancer: a systematic review and meta-analysis

J Wang, S Lu, Y Meng, W Fu, X Zhou - European Journal of Pharmacology, 2022 - Elsevier
Objective Preclinical and in vitro studies have shown that beta blockade affect colorectal
cancer growth and metastasis through the sympathetic nervous system. There is no …

Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage

WJ Tian, M Zhou, DR Qiu, JJ Chen, XZ Liu, JD Li… - Bioorganic …, 2022 - Elsevier
Four undescribed seco-polyprenylated acylphloroglucinols (seco-PAPs), elodeoidesones
AD (1–4), were characterized from Hypericum elodeoides. Compound 1 represents the 1, 6 …