Meningiomas are the most common primary intracranial tumors. There are no effective
medical therapies for meningioma patients, and new treatments have been encumbered by …

DNA methylation is an epigenetic modification that has consistently been shown to be linked
with a variety of human traits and diseases. Because DNA methylation is dynamic and …

Fewer than half of all patients with advanced-stage high-grade serous ovarian cancers
(HGSCs) survive more than five years after diagnosis, but those who have an exceptionally …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …

Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer
deaths in women. Here we present an integrated multi-omic analysis of 643 cervical …

As the master regulator in utero, the placenta is core to the Developmental Origins of Health
and Disease (DOHaD) hypothesis but is historically understudied. To identify placental gene …

Gliomas arising in the setting of neurofibromatosis type 1 (NF1) are heterogeneous,
occurring from childhood through adulthood, can be histologically low-grade or high-grade …

Background Obesity is a heritable complex phenotype that can increase the risk of age‐
related outcomes. Biological age can be estimated from DNA methylation (DNAm) using …

Hepatocellular carcinoma (HCC) is amongst the cancers with highest mortality rates and is
the most common malignancy of the liver. Early detection is vital to provide the best …

Although male–female differences in placental structure and function have been observed,
little is understood about their molecular underpinnings. Here, we present a mega-analysis …