The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis

MK Sen, DA Mahns, JR Coorssen, PJ Shortland - Glia, 2022 - Wiley Online Library
In human demyelinating diseases such as multiple sclerosis (MS), an imbalance between
demyelination and remyelination can trigger progressive degenerative processes. The …

Motor behavioral deficits in the cuprizone model: Validity of the rotarod test paradigm

C Lubrich, P Giesler, M Kipp - International journal of molecular sciences, 2022 - mdpi.com
Multiple Sclerosis (MS) is a neuroinflammatory disorder, which is histopathologically
characterized by multifocal inflammatory demyelinating lesions affecting both the central …

Sex differences in the behavioural aspects of the cuprizone-induced demyelination model in mice

KF Paton, S Hong, A Biggerstaff, BM Kivell - Brain Sciences, 2022 - mdpi.com
Multiple sclerosis is an autoimmune disease characterised by demyelination in the central
nervous system. The cuprizone-induced demyelination model is often used in mice to test …

Histological and top-down proteomic analyses of the visual pathway in the cuprizone demyelination model

MSM Almuslehi, MK Sen, PJ Shortland… - Journal of Molecular …, 2022 - Springer
A change in visual perception is a frequent early symptom of multiple sclerosis (MS), the
pathoaetiology of which remains unclear. Following a slow demyelination process caused …

Colony‐stimulating factor‐1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model

VSB Wies Mancini, AA Di Pietro… - Journal of …, 2022 - Wiley Online Library
Multiple sclerosis (MS), especially in its progressive phase, involves early axonal and
neuronal damage resulting from a combination of inflammatory mediators, demyelination …

Cuprizone feeding induces swollen astrocyte endfeet

P Fallier-Becker, I Bonzheim, F Pfeiffer - Pflügers Archiv-European Journal …, 2022 - Springer
The cuprizone model is a widely used model to study the pathogenesis of multiple sclerosis
(MS). Due to the selective loss of mature oligodendrocytes and myelin, it is mainly being …

[PDF][PDF] Therapeutic, Genetic, and Dietary Manipulation of Microglia to Understand The Pathogenesis of Female Neurological Disorders

ST Xavier - 2022 - researchrepository.rmit.edu.au
Multiple sclerosis (MS) is one of the most common demyelinating diseases of the central
nervous system (CNS). While the exact cause of MS is unknown, it is considered to be an …

An exploration into common mechanisms of oxidative damage in models of demyelinating disease and neurotrauma

LM Toomey - 2022 - espace.curtin.edu.au
This thesis explored common mechanisms of oxidative damage in multiple sclerosis and
neurotrauma and encompasses work that has been published in four journal articles …

Investigating The Effect Of A Herbal Phytoestrogen Compound In Cuprizone Model Of Multiple Sclerosis

RS Al-Dhahri, R Mansouri, GM Ashraf - platform.almanhal.com
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the
central nervous system (CNS) characterized by demyelination of nerves, and neural …