Ferroptosis is a kind of oxidative stress-dependent cell death characterized by iron
accumulation and lipid peroxidation. It can work in conjunction with radiation to increase …

Vascular endothelium plays a crucial role in vascular homeostasis and tissue fluid balance.
To target endothelium for robust genome editing, we developed poly (ethylene glycol) …

Background: Inflamed endothelial cells (ECs) trigger atherogenesis, especially at arterial
regions experiencing disturbed blood flow. UCP2 (Uncoupling protein 2), a key …

Endothelial defects significantly contribute to cardiovascular pathology in the premature
aging disease Hutchinson-Gilford progeria syndrome (HGPS). Using an endothelium …

6-Phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 (PFKFB3) is a powerful driver of
angiogenesis through its modulation of glycolytic metabolism within endothelial cells …

Sp1 transcription factor regulates genes involved in various phenomena of tumor
progression. Vasculogenic mimicry (VM) is the alternative neovascularization by aggressive …

Gene vectors targeting CNS endothelial cells allow to manipulate the blood-brain barrier
and to correct genetic defects in the CNS. Because vectors based on the adeno-associated …

Although atherosclerosis preferentially develops at arterial curvatures and bifurcations
where disturbed flow (DF) activates endothelium, therapies targeting flow-dependent …

An impairment to ischaemia-driven angiogenesis underpins the development of many
vascular complications in patients with diabetes. Angiogenesis is driven by endothelial cells …