Light at night is a pervasive problem in our society; over 80% of the world's population
experiences significant light pollution. Exacerbating this issue is the reality that artificially lit …

Aging is characterized by an increased vulnerability to infection and the development of
inflammatory diseases, such as atherosclerosis, frailty, cancer and neurodegeneration …

Evidence that glial cells influence behavior has been gaining a steady foothold in scientific
literature. Out of the five main subtypes of glial cells in the brain, astrocytes and microglia …

Microglia, the brain's resident macrophages, actively contribute to the homeostasis of
cerebral parenchyma by sensing neuronal activity and supporting synaptic remodeling and …

Circadian rhythm disruption (CRD) is a shared characteristic of various brain disorders, such
as Alzheimer's disease (AD), Parkinson's disease (PD), and major depression disorder …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder, and there is a
pressing need to identify disease‐modifying factors and devise interventional strategies. The …

Microglia are subject to change in tandem with the endogenously generated biological
oscillations known as our circadian rhythm. Studies have shown microglia harbor an intrinsic …

Improved understanding of the etiologies of delirium, a common and severe
neuropsychiatric syndrome, would facilitate the disease prevention and treatment. Here, the …

Circadian rhythms in most living organisms are regulated by light and synchronized to an
endogenous biological clock. The circadian clock machinery is also critically involved in …

Cell-autonomous, tissue-specific circadian rhythms in gene expression and cellular
processes have been observed throughout the human body. Disruption of daily rhythms by …