Generating specificity in genome regulation through transcription factor sensitivity to chromatin
Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …
Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer
The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin
remodelling and is altered in over 20% of cancers,. Here we developed a proteolysis …
remodelling and is altered in over 20% of cancers,. Here we developed a proteolysis …
Managing the steady state chromatin landscape by nucleosome dynamics
K Ahmad, S Henikoff… - Annual review of …, 2022 - annualreviews.org
Gene regulation arises out of dynamic competition between nucleosomes, transcription
factors, and other chromatin proteins for the opportunity to bind genomic DNA. The …
factors, and other chromatin proteins for the opportunity to bind genomic DNA. The …
Profiling and functional characterization of maternal mRNA translation during mouse maternal-to-zygotic transition
Translational regulation plays an important role in gene expression and function. Although
the transcriptional dynamics of mouse preimplantation embryos have been well …
the transcriptional dynamics of mouse preimplantation embryos have been well …
The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer
SA Patel, S Hirosue, P Rodrigues, E Vojtasova… - Nature, 2022 - nature.com
Large-scale human genetic data,–have shown that cancer mutations display strong tissue-
selectivity, but how this selectivity arises remains unclear. Here, using experimental models …
selectivity, but how this selectivity arises remains unclear. Here, using experimental models …
BAF complex maintains glioma stem cells in pediatric H3K27M glioma
Diffuse midline gliomas are uniformly fatal pediatric central nervous system cancers that are
refractory to standard-of-care therapeutic modalities. The primary genetic drivers are a set of …
refractory to standard-of-care therapeutic modalities. The primary genetic drivers are a set of …
Kinetic principles underlying pioneer function of GAGA transcription factor in live cells
How pioneer factors interface with chromatin to promote accessibility for transcription control
is poorly understood in vivo. Here, we directly visualize chromatin association by the …
is poorly understood in vivo. Here, we directly visualize chromatin association by the …
[HTML][HTML] Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
Reactivation of fetal hemoglobin expression by the downregulation of BCL11A is a
promising treatment for β-hemoglobinopathies. A detailed understanding of BCL11A …
promising treatment for β-hemoglobinopathies. A detailed understanding of BCL11A …
Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma
Activating KRAS mutations and functional loss of members of the SWI/SNF complex,
including ARID1A, are found together in the primary liver tumor cholangiocarcinoma (CC) …
including ARID1A, are found together in the primary liver tumor cholangiocarcinoma (CC) …
Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers
O Hendy, L Serebreni, K Bergauer, F Muerdter… - Molecular cell, 2022 - cell.com
Gene transcription is a highly regulated process in all animals. In Drosophila, two major
transcriptional programs, housekeeping and developmental, have promoters with distinct …
transcriptional programs, housekeeping and developmental, have promoters with distinct …