Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept
N Hernandez‐Pacheco, M Kere… - Pediatric Allergy and …, 2022 - Wiley Online Library
Investigation of gene‐environment interactions (GxE) may provide important insights into the
gene regulatory framework in response to environmental factors of relevance for childhood …
gene regulatory framework in response to environmental factors of relevance for childhood …
[HTML][HTML] S3 guideline allergy prevention
MV Kopp, C Muche-Borowski, M Abou-Dakn… - Allergologie …, 2022 - ncbi.nlm.nih.gov
Background: The persistently high prevalence of allergic diseases in Western industrial
nations and the limited possibilities of causal therapy make evidence-based …
nations and the limited possibilities of causal therapy make evidence-based …
Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology
SP Sajuthi, JL Everman, ND Jackson, B Saef… - Nature …, 2022 - nature.com
To identify genetic determinants of airway dysfunction, we performed a transcriptome-wide
association study for asthma by combining RNA-seq data from the nasal airway epithelium …
association study for asthma by combining RNA-seq data from the nasal airway epithelium …
A common IL‐4 receptor variant promotes asthma severity via a Treg cell GRB2‐IL‐6‐Notch4 circuit
Background The mechanisms by which genetic and environmental factors interact to
promote asthma remain unclear. Both the IL‐4 receptor alpha chain R576 (IL‐4RαR576) …
promote asthma remain unclear. Both the IL‐4 receptor alpha chain R576 (IL‐4RαR576) …
Epigenome-wide association study of lung function in Latino children and youth with asthma
Introduction DNA methylation studies have associated methylation levels at different CpG
sites or genomic regions with lung function. Moreover, genetic ancestry has been associated …
sites or genomic regions with lung function. Moreover, genetic ancestry has been associated …
Genetic ancestry to improve precision of race/ethnicity–based lung function equations in children
J Witonsky, JR Elhawary, C Eng… - American Journal of …, 2022 - atsjournals.org
Methods Spirometric predictions and genetic ancestry proportions were calculated using
data collected in two parallel case-control studies of asthma (2006–2014): the GALA II …
data collected in two parallel case-control studies of asthma (2006–2014): the GALA II …
Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness
Variability in response to short-acting β2-agonists (eg, albuterol) among patients with
asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to …
asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to …
Understanding racial disparities in childhood asthma using individual-and neighborhood-level risk factors
E Correa-Agudelo, L Ding, AF Beck, C Brokamp… - Journal of Allergy and …, 2022 - Elsevier
Background Racial disparities in childhood asthma outcomes result from a complex
interplay of individual-and neighborhood-level factors. Objectives We sought to examine …
interplay of individual-and neighborhood-level factors. Objectives We sought to examine …
Air quality index and emergency department visits and hospitalizations for childhood asthma
F Rosser, YY Han, SD Rothenberger… - Annals of the …, 2022 - atsjournals.org
Rationale: Outdoor air pollution causes emergency department visits and hospitalizations for
childhood asthma. In the United States, the Air Quality Index (AQI) alerts the public to air …
childhood asthma. In the United States, the Air Quality Index (AQI) alerts the public to air …
Environmental effects on acute exacerbations of respiratory diseases: A real-world big data study
Background The effects of weather periods, race/ethnicity, and sex on environmental
triggers for respiratory exacerbations are not well understood. This study linked the …
triggers for respiratory exacerbations are not well understood. This study linked the …