Investigation of gene‐environment interactions (GxE) may provide important insights into the
gene regulatory framework in response to environmental factors of relevance for childhood …

Background: The persistently high prevalence of allergic diseases in Western industrial
nations and the limited possibilities of causal therapy make evidence-based …

To identify genetic determinants of airway dysfunction, we performed a transcriptome-wide
association study for asthma by combining RNA-seq data from the nasal airway epithelium …

Background The mechanisms by which genetic and environmental factors interact to
promote asthma remain unclear. Both the IL‐4 receptor alpha chain R576 (IL‐4RαR576) …

Introduction DNA methylation studies have associated methylation levels at different CpG
sites or genomic regions with lung function. Moreover, genetic ancestry has been associated …

Methods Spirometric predictions and genetic ancestry proportions were calculated using
data collected in two parallel case-control studies of asthma (2006–2014): the GALA II …

Variability in response to short-acting β2-agonists (eg, albuterol) among patients with
asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to …

Background Racial disparities in childhood asthma outcomes result from a complex
interplay of individual-and neighborhood-level factors. Objectives We sought to examine …

Rationale: Outdoor air pollution causes emergency department visits and hospitalizations for
childhood asthma. In the United States, the Air Quality Index (AQI) alerts the public to air …

Background The effects of weather periods, race/ethnicity, and sex on environmental
triggers for respiratory exacerbations are not well understood. This study linked the …