All endocrine glands are susceptible to neoplastic growth, yet the health consequences of
these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent …

Growth hormone-secreting pituitary adenomas that cause acromegaly arise as monoclonal
expansions of differentiated somatotroph cells and are usually sporadic. They are almost …

Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Due
to its extensive tumor heterogeneity and the lack of high-quality tissues for biomarker …

Corticotroph macroadenomas are rare but difficult to manage intracranial neoplasms.
Mutations in the two Cushing's disease mutational hotspots USP8 and USP48 are less …

Pituitary tumors are generally benign, although in rare cases aggressive pituitary tumors
(APTs) and carcinomas present important diagnostic and therapeutic challenges and are …

Corticotroph tumours are primarily sporadic monoclonal neoplasms and only rarely found in
genetic syndromes. Recurrent mutations in the ubiquitin specific protease 8 (USP8) gene …

The clinical characteristics of growth hormone (GH)-producing pituitary adenomas/
somatotroph pituitary neuroendocrine tumors (GHomas/somatotroph PitNETs) vary across …

Pituitary tumorigenesis is highly prevalent and causes major endocrine disorders. Hardly
anything is known on the behavior of the local stem cells in this pathology. Here, we …

A pituitary adenoma (PA) is a common intracranial neoplasm, and is a complex, chronic, and
whole‐body disease with multicausing factors, multiprocesses, and multiconsequences. It is …

Prolactinomas account for approximately 50% of all pituitary adenomas coming to medical
attention and are an important cause of hypogonadism and infertility. The ultimate goal of …