Pharmacological effects and underlying mechanisms of licorice‐derived flavonoids

Y Wu, Z Wang, Q Du, Z Zhu, T Chen… - Evidence‐Based …, 2022 - Wiley Online Library
Glycyrrhizae Radix et Rhizoma is the most frequently prescribed natural medicine in China
and has been used for more than 2,000 years. The flavonoids of licorice have garnered …

Holism of Chinese herbal medicine prescriptions for inflammatory bowel disease: A review based on clinical evidence and experimental research

S Zhang, H Luo, D Tan, B Peng, Z Zhong, Y Wang - Phytomedicine, 2022 - Elsevier
Background Inflammatory bowel disease (IBD) is a chronic nonspecific inflammatory
disease that causes a heavy burden and lacks effective treatments. Chinese herbal …

Colon-specific delivery of isoliquiritigenin by oral edible zein/caseate nanocomplex for ulcerative colitis treatment

M Xiao, S Wu, Y Cheng, J Ma, X Luo, L Chang… - Frontiers in …, 2022 - frontiersin.org
Although a natural anti-inflammatory ingredient, isoliquiritigenin (ISL), plays an effective role
in ulcerative colitis (UC) treatment, a series of drawbacks still limit its clinical application …

Anti-inflammation of isoliquiritigenin via the inhibition of NF-κB and MAPK in LPS-stimulated MAC-T cells

M Li, G Lu, X Ma, R Wang, X Chen, Y Yu… - BMC Veterinary …, 2022 - Springer
Background The application of plant extracts has received great interest for the treatment of
bovine mastitis. Isoliquiritigenin (ISL) is a rich dietary flavonoid that has significant …

Hydroxysafflor yellow A protects against ulcerative colitis via suppressing TLR4/NF‐κB signaling pathway

Z Feng, P Zhou, X Wu, J Zhang… - Chemical Biology & …, 2022 - Wiley Online Library
Hydroxysafflower yellow A (HSYA) protects against acute kidney injury through TLR4/NF‐κB
pathway. However, the effect and potential mechanism of HSYA in ulcerative colitis (UC) …

Preclinical studies of licorice in ulcerative colitis: a systematic review with meta-analysis and network pharmacology

PD Lu, MC Yuan, XP Quan, JF Chen… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Licorice, as a traditional Chinese herbal medicine,
possessing the efficacies of invigorating spleen and replenishing qi, heat-clearing and …

[HTML][HTML] Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR 4/NF-κB pathway and protecting the intestinal barrier

B Yan, X Li, L Zhou, Y Qiao, J Wu, L Zha… - Bosnian Journal of …, 2022 - ncbi.nlm.nih.gov
Abstract Interleukin-1 receptor-associated kinase 1/4 (IRAK1/4) is the main kinase of the toll-
like receptor (TLR)-mediated pathway, considered a new target for treating inflammatory …

[HTML][HTML] Spenceria ramalana Trimen total polyphenols modulate the inflammatory response and intestinal flora in DSS-induced ulcerative colitis in C57BL/6 mice

M Tan, L Wang, K Guan, CC Li, C Chen - … Research-Modern Chinese …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Spenceria ramalana Trimen is a perennial herb of
the genus Spenceria in the family Rosaceae, the roots of which can be used as medicine. It …

Chemical Characterization and Metabolic Profiling of the Compounds in the Chinese Herbal Formula Li Chang Decoction by UPLC‐QTOF/MS

B Lin, S Guo, X Hong, X Jiang, H Li, J Li… - Evidence‐Based …, 2022 - Wiley Online Library
Background. Li Chang decoction (LCD), a Chinese medicine formula, is commonly used to
treat ulcerative colitis (UC) in clinics. Purpose. This study aimed to identify the major …

The Alleviation of Dextran Sulfate Sodium (DSS)-Induced Colitis Correlate with the logP Values of Food-Derived Electrophilic Compounds

XR Cheng, BT Yu, J Song, JH Ma, YY Chen, CX Zhang… - Antioxidants, 2022 - mdpi.com
Food-derived electrophilic compounds (FECs) are small molecules with electrophilic groups
with potential cytoprotective effects. This study investigated the differential effects of six …